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dc.contributor.author Cantero, Maria del Rocio
dc.contributor.author Villa Etchegoyen, Cecilia
dc.contributor.author Pérez, Paula Luciana
dc.contributor.author Scarinci, María Noelia
dc.contributor.author Cantiello, Horacio Fabio
dc.date.available 2019-09-11T14:08:37Z
dc.date.issued 2018-12
dc.identifier.citation Cantero, Maria del Rocio; Villa Etchegoyen, Cecilia; Pérez, Paula Luciana; Scarinci, María Noelia; Cantiello, Horacio Fabio; Bundles of Brain Microtubules Generate Electrical Oscillations; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-10
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/11336/83329
dc.description.abstract Microtubules (MTs) are long cylindrical structures of the cytoskeleton that control cell division, intracellular transport, and the shape of cells. MTs also form bundles, which are particularly prominent in neurons, where they help define axons and dendrites. MTs are bio-electrochemical transistors that form nonlinear electrical transmission lines. However, the electrical properties of most MT structures remain largely unknown. Here we show that bundles of brain MTs spontaneously generate electrical oscillations and bursts of electrical activity similar to action potentials. Under intracellular-like conditions, voltage-clamped MT bundles displayed electrical oscillations with a prominent fundamental frequency at 39 Hz that progressed through various periodic regimes. The electrical oscillations represented, in average, a 258% change in the ionic conductance of the MT structures. Interestingly, voltage-clamped membrane-permeabilized neurites of cultured mouse hippocampal neurons were also capable of both, generating electrical oscillations, and conducting the electrical signals along the length of the structure. Our findings indicate that electrical oscillations are an intrinsic property of brain MT bundles, which may have important implications in the control of various neuronal functions, including the gating and regulation of cytoskeleton-regulated excitable ion channels and electrical activity that may aid and extend to higher brain functions such as memory and consciousness.
dc.format application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Microtubules
dc.subject Electrical Oscillations
dc.subject Microtubules
dc.subject.classification Otras Medicina Básica
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Otras Medicina Básica
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Bundles of Brain Microtubules Generate Electrical Oscillations
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-08-30T14:27:14Z
dc.journal.volume 8
dc.journal.number 1
dc.journal.pagination 1-10
dc.journal.pais Estados Unidos
dc.description.fil Fil: Cantero, Maria del Rocio. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina
dc.description.fil Fil: Villa Etchegoyen, Cecilia. Universidad de Buenos Aires; Argentina
dc.description.fil Fil: Pérez, Paula Luciana. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina
dc.description.fil Fil: Scarinci, María Noelia. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina
dc.description.fil Fil: Cantiello, Horacio Fabio. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina
dc.journal.title Scientific Reports
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-018-30453-2
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/s41598-018-30453-2
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)