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dc.contributor.author
Recouvreux, Maria Victoria
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Camilletti, María Andrea
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Rifkin, Daniel B.
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Becu, Damasia
dc.contributor.author
Diaz, Graciela Susana
dc.date.available
2016-11-23T21:09:57Z
dc.date.issued
2012-06-14
dc.identifier.citation
Recouvreux, Maria Victoria; Camilletti, María Andrea; Rifkin, Daniel B.; Becu, Damasia; Diaz, Graciela Susana; Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT- 898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-b1 (TGF-b1); Endocrine Society; Endocrinology; 153; 8; 14-6-2012; 3861-3871
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/8325
dc.description.abstract
Prolactinomas are the most prevalent type of secreting pituitary tumors in humans and generally respond well to a medical therapy with dopamine agonists. However, for patients exhibiting resistance to dopaminergic drugs, alternative treatments are desired. Antiangiogenic strategies might represent a potential therapy for these tumors. Thrombospondin 1 (TSP-1) is a large multifunctional glycoprotein involved in multiple biological processes including angiogenesis, apoptosis, and activation of TGF- 1. Because tumors that overexpress TSP-1 grow more slowly, have fewer metastases, and have decreased angiogenesis, TSP-1 provides a novel target for cancer treatment. ABT-510 and ABT-898 are TSP-1 synthetic analogs that mimic its antiangiogenic action. In the present study, we explored the potential effect of ABT-510 and ABT-898 on experimental prolactinomas induced by chronic diethylstilbestrol (DES) treatment in female rats. We demonstrated that a 2-wk treatment with ABT-510 and ABT-898 counteracted the increase in pituitary size and serum prolactin levels as well as the pituitary proliferation rate induced by DES. These inhibitory effects on tumor growth could be mediated by the antiangiogenic properties of the drugs. We also demonstrated that ABT-510 and ABT-898, in addition to their described antiangiogenic effects, increased active TGF- 1 level in the tumors. We postulate that the recovery of the local cytokine activation participates in the inhibition of lactotrope function. These results place these synthetic TSP-1 analogs as potential alternative or complementary treatments in dopamine agonist-resistant prolactinomas.
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application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Prolactin
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Thrombospondin
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Tgf Beta
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Ltbp
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Oligopeptides
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT- 898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-b1 (TGF-b1)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-22T21:22:05Z
dc.identifier.eissn
1945-7170
dc.journal.volume
153
dc.journal.number
8
dc.journal.pagination
3861-3871
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Los Angeles
dc.description.fil
Fil: Recouvreux, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Cedars Sinai Medical Center; Estados Unidos
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Fil: Camilletti, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
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Fil: Rifkin, Daniel B.. New York University Medical Center; Estados Unidos
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Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/en.2012-1007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://press.endocrine.org/doi/10.1210/en.2012-1007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404347/
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