Artículo

Cytotoxic and Antitumor Activity of some Coumarin Derivatives

Garro, Hugo AlejandroIcon ; Reta, Guillermo FedericoIcon ; Donadel, Osvaldo Juan; Pungitore, Carlos RodolfoIcon
Fecha de publicación: 09/2016
Editorial: SAGE Publications
Revista: Natural Product Communications
ISSN: 1934-578X
e-ISSN: 1555-9475
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Several natural and synthetic coumarins were assayed against different cancer cell lines. Four of them have shown cytotoxicity against a panel of three human solid tumor cell lines (HeLa, T-47D, and WiDr) and a clearly activity/hydrophobicity relationship. Compound 13 proved to be the most active product in all cell lines tested, with values of 8.0 (±0.38) μM against HeLa cells and also able to inhibit Taq DNA polymerase. This dual activity of 13 makes it a candidate to be considered as a "lead" compound in the search for novel antitumor drugs.
Palabras clave: Coumarins , Antitumor , Cell Lines , Replicarion Inhibition , Lipophilicity
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/83095
DOI: http://dx.doi.org/10.1177/1934578X1601100926
URL: https://journals.sagepub.com/doi/abs/10.1177/1934578X1601100926
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Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Citación
Garro, Hugo Alejandro; Reta, Guillermo Federico; Donadel, Osvaldo Juan; Pungitore, Carlos Rodolfo; Cytotoxic and Antitumor Activity of some Coumarin Derivatives; SAGE Publications; Natural Product Communications; 11; 9; 9-2016; 1289-1292
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