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dc.contributor.author
Castro, Gerardo Daniel  
dc.contributor.author
Delgado De Layño, Aurora, M. A.  
dc.contributor.author
Costantini, Martin Hernan  
dc.contributor.author
Castro, Jose Alberto  
dc.date.available
2019-09-02T19:24:25Z  
dc.date.issued
2002-05  
dc.identifier.citation
Castro, Gerardo Daniel; Delgado De Layño, Aurora, M. A.; Costantini, Martin Hernan; Castro, Jose Alberto; Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: Its potential contribution to prostate tumor promotion; Wiley; Teratogenesis Carcinogenesis And Mutagenesis; 22; 5; 5-2002; 335-341  
dc.identifier.issn
0270-3211  
dc.identifier.uri
http://hdl.handle.net/11336/82751  
dc.description.abstract
Rat ventral prostate microsomal fraction was able to biotransform ethanol to acetaldehyde and 1-hydroxyethyl radicals (1HEt) in the presence of NADPH and oxygen. The enzymatic processes involved were not inhibited by desferrioxamine, CO, SKF 525A, 4-methylpyrazole, or polyclonal antibody against P450 reductase but they were significantly inhibited by diethyldithiocarbamate, 2-mercapto-1-methylimidazol, thiobenzamide, or diphenyleneiodonium chloride. Results would suggest the partial participation in these ethanol bioactivation processes of flavin containing monooxygenase (FMO) and/or other flavin dependent oxidases/ peroxidases and of a non-iron metal-containing enzymes. Acetaldehyde and free radicals production by prostate microsomal fraction might potentially contribute to tumor promotion in heavy alcohol drinkers.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Alcohol  
dc.subject
Cancer  
dc.subject
Free Radicals  
dc.subject
Gc-Ms  
dc.subject
Spin Trapping  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: Its potential contribution to prostate tumor promotion  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-08-26T18:36:42Z  
dc.journal.volume
22  
dc.journal.number
5  
dc.journal.pagination
335-341  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Hoboken  
dc.description.fil
Fil: Castro, Gerardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina  
dc.description.fil
Fil: Delgado De Layño, Aurora, M. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina  
dc.description.fil
Fil: Costantini, Martin Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina  
dc.description.fil
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina  
dc.journal.title
Teratogenesis Carcinogenesis And Mutagenesis  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/tcm.10028  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/tcm.10028  

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