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dc.contributor.author
Simian, Marina  
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Manzur, Teresita  
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Rodriguez, Vanina  
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Bal, Elisa Dora  
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Klein, Slobodanka Mariana  
dc.date.available
2019-08-30T19:58:16Z  
dc.date.issued
2009-01  
dc.identifier.citation
Simian, Marina; Manzur, Teresita; Rodriguez, Vanina; Bal, Elisa Dora; Klein, Slobodanka Mariana; A spontaneous estrogen dependent, tamoxifen sensitive mouse mammary tumor: A new model system to study hormone-responsiveness in immune competent mice; Springer; Breast Cancer Research and Treatment; 113; 1; 1-2009; 1-8  
dc.identifier.issn
0167-6806  
dc.identifier.uri
http://hdl.handle.net/11336/82661  
dc.description.abstract
Currently, an in vivo spontaneous model of estrogen dependent, tamoxifen sensitive breast cancer does not exist. We show here the characterization of the M05 mammary tumor that appeared spontaneously in a 1-year-old virgin female BALB/c mouse in our animal facility. The M05 tumor is a semi-differentiated adenocarcinoma that expresses estrogen and progesterone receptors. When it was transplanted to either male or ovariectomized female mice it did not grow. Moreover, ovariectomy or treatment with tamoxifen of tumor bearing mice led to a halt in tumor growth. Treatment of ovariectomized mice that had been inoculated with the M05 tumor showed that only estradiol, but not progesterone, promoted the re-growth of the tumor. Finally, after passage nine, tumor growth was achieved in male and ovariectomized female mice suggesting that the tumor had progressed to hormone independence. However, like often found in the clinic, expression of estrogen and progesterone receptors was maintained. This model mimics the biology of estrogen receptor positive breast cancer in humans and presents itself as an invaluable tool for the study of endocrine resistance in a physiologically relevant setting.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Breast Cancer  
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Estrogen Dependent  
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In Vivo Mouse Model  
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Tamoxifen Sensitive  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
A spontaneous estrogen dependent, tamoxifen sensitive mouse mammary tumor: A new model system to study hormone-responsiveness in immune competent mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-05-08T18:27:48Z  
dc.identifier.eissn
1573-7217  
dc.journal.volume
113  
dc.journal.number
1  
dc.journal.pagination
1-8  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlín  
dc.description.fil
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Manzur, Teresita. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Rodriguez, Vanina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Klein, Slobodanka Mariana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Breast Cancer Research and Treatment  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10549-007-9888-x  
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info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10549-007-9888-x