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dc.contributor.author
Bardagi, Javier Ivan
dc.contributor.author
Rossi, Roberto Arturo
dc.date.available
2019-08-30T18:23:01Z
dc.date.issued
2009-01
dc.identifier.citation
Bardagi, Javier Ivan; Rossi, Roberto Arturo; Advances in the synthesis of 5-and 6-substituted uracil derivatives; Routledge Journals, Taylor & Francis Ltd; Organic Preparations and Procedures International; 41; 6; 1-2009; 479-514
dc.identifier.issn
0030-4948
dc.identifier.uri
http://hdl.handle.net/11336/82620
dc.description.abstract
The uracil unit is one of the most important structures in life, it being part of the building blocks of RNA and DNA and other natural products; therefore, it is not surprising that uracil derivatives have important biological activity. Uracil-based compounds are used in the treatment of cancer (5-fluoruracil) and against infections of the HIV virus (AZT). Actions as antiviral and antitumoral agents are perhaps the most widely reported activity. However, other uracil derivatives have been synthesized which are herbicides, insecticides, bactericides, acaricides, etc. In addition, uracil units can be found in the chemistry of peptide nucleic acid (PNA) or as part of other fused systems with antiallergic, antihypertensive, cardiotonic, bronchodilator or antibronchitis activity.The search for uracil derivatives has been carried out since the beginning of the last century and even today there is great interest in the development of new derivatives and strategies for synthesis so as to improve the yield of known compounds. To prepare uracils, there are three main synthetic strategies: a) building the uracil nucleus from acyclic precursors with appropriate substituents; b)modification of the structure of functionalized uracils or uracil itself by reaction with different reagents, as the recent synthesis of 5-trifluoromethyluracil and uridines with oxiranyl and tetrahydrofuranyl substituents; c) functionalization of masked uracil moieties with reactions incompatible with the nucleus, for example the synthesis of 6-aryl and 6- acyluracils and 2 -eoxypseudouridine. Combinations of these approaches are often found in the synthesis of target compounds with potential biological activities.The present review will cover advances in the synthesis of 5- and 6-substituted uracils over the last 8-10 years. This review has been organized in terms of the type of union that links the uracil moieties to the substitution groups; fused systems will have a separate section.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Routledge Journals, Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mini Review
dc.subject
Synthesis
dc.subject
5- And 6- Derivates
dc.subject
Uracil
dc.subject.classification
Química Orgánica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Advances in the synthesis of 5-and 6-substituted uracil derivatives
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-06T14:17:15Z
dc.identifier.eissn
1945-5453
dc.journal.volume
41
dc.journal.number
6
dc.journal.pagination
479-514
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bardagi, Javier Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Rossi, Roberto Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.journal.title
Organic Preparations and Procedures International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/00304940903378776
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/00304940903378776


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