Mostrar el registro sencillo del ítem
dc.contributor.author
Lauro, Augusto
dc.contributor.author
D'Amico, Francesco
dc.contributor.author
Gondolesi, Gabriel Eduardo
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2019-08-30T17:22:36Z
dc.date.issued
2017-12
dc.identifier.citation
Lauro, Augusto; D'Amico, Francesco; Gondolesi, Gabriel Eduardo; The current therapeutic options for Crohn’s disease: from medical therapy to intestinal transplantation; Taylor & Francis; Expert Review of Gastroenterology and Hepatology; 11; 12; 12-2017; 1105-1117
dc.identifier.issn
1747-4124
dc.identifier.uri
http://hdl.handle.net/11336/82600
dc.description.abstract
Introduction: Crohn’s disease (CD) has an annual incidence per 100.000 person-year of 20.2 in North America and 12.7 in Europe, and the purpose of this review is to evaluate its medical management, from diagnosis to transplant. Pharmacologic manipulation with nutritional care aims to achieve and maintain remission, but more than half of patients will undergo an intestinal resection, very often repeated over time. They could experience short bowel syndrome (SBS) requiring total parenteral nutrition (TPN). Intestinal transplantation (ITx) represents an alternative in case of irreversible intestinal failure (IF) with life-threatening TPN complications. Patient survival after ITx is 79%, 53% and 43% at 1, 3 and 5 years respectively, with no differences among ITx for other disorders. Areas covered: The research discussed medical therapy with nutritional support, evaluating the role of endoscopy, surgery and transplant in CD. A systematic literature review was conducted using the PubMed search engine up to May 31th, 2017 without restriction of the language. The decision on paper’s eligibility was reached by consensus between the 3 screening authors. Expert commentary: CD treatment is mainly medical, leaving endoscopy and surgery for a complex course. ITx represents a therapeutic option if TPN complications with IF arise.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Crohn’S Disease
dc.subject
Intestinal Transplantation
dc.subject
Medical Therapy
dc.subject
Surgical Management
dc.subject
Tpn
dc.subject.classification
Trasplantes
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Clínica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
The current therapeutic options for Crohn’s disease: from medical therapy to intestinal transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-08-30T14:28:45Z
dc.identifier.eissn
1747-4132
dc.journal.volume
11
dc.journal.number
12
dc.journal.pagination
1105-1117
dc.journal.pais
Reino Unido
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Lauro, Augusto. Universidad de Bologna; Italia
dc.description.fil
Fil: D'Amico, Francesco. Azienda Ospedaliera Di Padova; Italia
dc.description.fil
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
dc.journal.title
Expert Review of Gastroenterology and Hepatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/17474124.2017.1367665
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17474124.2017.1367665
Archivos asociados