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dc.contributor.author
Danilovich, Mariana Elizabeth  
dc.contributor.author
Sanchez, Leandro Arturo  
dc.contributor.author
Acosta, Federico Francisco  
dc.contributor.author
Delgado, Osvaldo Daniel  
dc.date.available
2019-08-28T14:33:10Z  
dc.date.issued
2018-07  
dc.identifier.citation
Danilovich, Mariana Elizabeth; Sanchez, Leandro Arturo; Acosta, Federico Francisco; Delgado, Osvaldo Daniel; Antarctic bioprospecting: in pursuit of microorganisms producing new antimicrobials and enzymes; Springer; Polar Biology; 41; 7; 7-2018; 1417-1433  
dc.identifier.issn
0722-4060  
dc.identifier.uri
http://hdl.handle.net/11336/82355  
dc.description.abstract
Intensive efforts are being made to find new compounds with antimicrobial activity. The search for these novel bio-products in sparsely explored environments may be the key to providing solutions for many emerging problems. Antarctic environments are valuable locations for bioprospecting. In this study, 63 cold-adapted bacterial strains of 6100 different colony morphotypes were isolated from Antarctic seawater samples around South Shetland and Deception islands. Strains were selected based on cold-active antimicrobial production and were grouped into 11 operational taxonomic units by internal spacer region-PCR and amplified ribosomal DNA restriction analysis. Isolates arbitrarily named 2D, 5D, and 6D were closely related to Halomonas titanicae, with 99.8, 98.9, and 96.7% identity according to 16S rDNA sequencing, and 99.7, 99.3, and 98.3% according to gyrB region sequence analysis, respectively. The isolate 18SH was closely related to Candida sake (99.2%) based on sequence analysis of the ITS1?5.8S rDNA?ITS2 and D1/D2 domain of 26S rDNA. Antimicrobials produced by isolates 2D, 5D, and 6D exhibited a low-molecular weight (< 6000 Da) and stability in wide pH and temperature ranges. When tested against foodborne and phytopathogenic bacteria, selected isolates exhibited a wide spectrum of activity. This work reports the isolation and identification of cold-adapted microorganisms with the ability to produce antimicrobial compounds with potential application in the pharmaceutical or in cold-chain management in the food industry. The current results highlight the potential of the Antarctic environment as a valuable and underexploited source of new antimicrobial molecules with exceptional properties for different biotechnological applications.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antarctica  
dc.subject
Antimicrobial  
dc.subject
Bioprospection  
dc.subject
Enzyme  
dc.subject
Psychrophile  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Antarctic bioprospecting: in pursuit of microorganisms producing new antimicrobials and enzymes  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-08-27T13:29:04Z  
dc.journal.volume
41  
dc.journal.number
7  
dc.journal.pagination
1417-1433  
dc.journal.pais
Alemania  
dc.journal.ciudad
Heidelbergç  
dc.description.fil
Fil: Danilovich, Mariana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina  
dc.description.fil
Fil: Sanchez, Leandro Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina  
dc.description.fil
Fil: Acosta, Federico Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina  
dc.description.fil
Fil: Delgado, Osvaldo Daniel. Universidad Nacional de Catamarca; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina  
dc.journal.title
Polar Biology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00300-018-2295-4  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s00300-018-2295-4