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Artículo

Stromal cell expression of caveolin-1 predicts outcome in breast cancer

Sloan, Erica K.; Ciocca, Daniel RamonIcon ; Pouliot, Normand; Natoli, Anthony; Restall, Christina; Henderson, Michael A.; Fanelli, Mariel AndreaIcon ; Cuello Carrión, Fernando DaríoIcon ; Gago, Francisco E.; Anderson, Robin L.
Fecha de publicación: 06/2009
Editorial: Elsevier
Revista: American Journal Of Pathology
ISSN: 0002-9440
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Oncología

Resumen

Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.
Palabras clave: Caveolin-1 , Breast Cancer , Stromal Expression , Prognostic Factor
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/82326
DOI: http://dx.doi.org/10.2353/ajpath.2009.080924
URL: https://www.sciencedirect.com/science/article/pii/S0002944010610632
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Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Sloan, Erica K.; Ciocca, Daniel Ramon; Pouliot, Normand; Natoli, Anthony; Restall, Christina; et al.; Stromal cell expression of caveolin-1 predicts outcome in breast cancer; Elsevier; American Journal Of Pathology; 174; 6; 6-2009; 2035-2043
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