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dc.contributor.author
Mackern Oberti, Juan Pablo
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Vega, Fabián
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Llanos, Carolina
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Bueno, Susan
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Kalergis, Alexis
dc.date.available
2019-08-27T21:58:05Z
dc.date.issued
2014-09
dc.identifier.citation
Mackern Oberti, Juan Pablo; Vega, Fabián; Llanos, Carolina; Bueno, Susan; Kalergis, Alexis; Targeting dendritic cell function during systemic autoimmunity to restore tolerance; MDPI; International Journal of Molecular Sciences; 15; 9; 9-2014; 16381-16417
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/82318
dc.description.abstract
Systemic autoimmune diseases can damage nearly every tissue or cell type of the body. Although a great deal of progress has been made in understanding the pathogenesis of autoimmune diseases, current therapies have not been improved, remain unspecific and are associated with significant side effects. Because dendritic cells (DCs) play a major role in promoting immune tolerance against self-antigens (self-Ags), current efforts are focusing at generating new therapies based on the transfer of tolerogenic DCs (tolDCs) during autoimmunity. However, the feasibility of this approach during systemic autoimmunity has yet to be evaluated. TolDCs may ameliorate autoimmunity mainly by restoring T cell tolerance and, thus, indirectly modulating autoantibody development. In vitro induction of tolDCs loaded with immunodominant self-Ags and subsequent cell transfer to patients would be a specific new therapy that will avoid systemic immunosuppression. Herein, we review recent approaches evaluating the potential of tolDCs for the treatment of systemic autoimmune disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Autoimmunity
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Dendritic Cells
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Therapy
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Tolerance
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Targeting dendritic cell function during systemic autoimmunity to restore tolerance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-11T15:15:01Z
dc.journal.volume
15
dc.journal.number
9
dc.journal.pagination
16381-16417
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Mackern Oberti, Juan Pablo. Pontificia Universidad Católica de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Vega, Fabián. Pontificia Universidad Católica de Chile; Chile
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Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
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Fil: Bueno, Susan. Pontificia Universidad Católica de Chile; Chile. Inserm; Francia
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Fil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms150916381
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/15/9/16381
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