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dc.contributor.author
López Fontana, Constanza Matilde
dc.contributor.author
Maselli, María Eugenia
dc.contributor.author
Salicioni, Ana M.
dc.contributor.author
Caron, Ruben Walter
dc.date.available
2019-08-27T21:32:02Z
dc.date.issued
2012-05
dc.identifier.citation
López Fontana, Constanza Matilde; Maselli, María Eugenia; Salicioni, Ana M.; Caron, Ruben Walter; The inhibitory effect of progesterone on lactogenesis during pregnancy is already evident by mid- to late gestation in rodents; Csiro Publishing; Reproduction Fertility and Development; 24; 5; 5-2012; 704-714
dc.identifier.issn
1031-3613
dc.identifier.uri
http://hdl.handle.net/11336/82309
dc.description.abstract
Lactogenesis is a very complex process highly dependent on hormonal regulation. In the present study the time-course of the inhibitory actions of progesterone on prolactin secretion, mammary gland morphology and lactogenesis from mid- to late gestation in rodents was investigated. Groups of pregnant rats were luteectomised or administered with mifepristone on Day 10, 13, 15 or 17 of gestation and decapitated 28 or 48h later. Whole-blood samples and the inguinal mammary glands were taken for determinations of hormone levels and for measurement of mammary content of casein and lactose and for tissue morphology analyses, respectively. Luteectomy or mifepristone evoked prolactin increases only after Day 17 of gestation. Mammary content of casein was increased by both treatments regardless of timing or duration. Mifepristone was less effective than luteectomy in inducing lactose production and the effect was only observed after Day 15 of gestation. Analysis of mammary gland morphology confirmed the observed effect of progesterone on lactogenesis. Both treatments triggered remarkable secretory activity in the mammary gland, even without a parallel epithelial proliferation, demonstrating that the mammary epithelium is able to synthesise milk compounds long before its full lobulo-alveolar development is achieved, provided that progesterone action is abolished. Thus, the present study demonstrates that progesterone is a potent hormonal switch for the prolactin and prolactin-like effects on mammary gland development and its milk-synthesising capacity during pregnancy, and that its inhibitory action is already evident by mid-pregnancy in rodents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Csiro Publishing
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Corpus Luteum
dc.subject
Lactation
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Mammary Gland
dc.subject.classification
Otras Ciencias de la Salud
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The inhibitory effect of progesterone on lactogenesis during pregnancy is already evident by mid- to late gestation in rodents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T21:51:30Z
dc.journal.volume
24
dc.journal.number
5
dc.journal.pagination
704-714
dc.journal.pais
Australia
dc.journal.ciudad
Collingwood
dc.description.fil
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Maselli, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Salicioni, Ana M.. University Of Massachusetts Amherst; Estados Unidos
dc.description.fil
Fil: Caron, Ruben Walter. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Reproduction Fertility and Development
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.publish.csiro.au/paper/RD11160.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1071/RD11160


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