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dc.contributor.author
Montalto, Maria
dc.contributor.author
Bartel, Laura Cecilia
dc.contributor.author
Rodríguez de Castro, Carmen
dc.contributor.author
Castro, Jose Alberto
dc.date.available
2019-08-26T18:08:01Z
dc.date.issued
2008-09
dc.identifier.citation
Montalto, Maria; Bartel, Laura Cecilia; Rodríguez de Castro, Carmen; Castro, Jose Alberto; Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 103; 6; 9-2008; 549-553
dc.identifier.issn
0074-0276
dc.identifier.uri
http://hdl.handle.net/11336/82108
dc.description.abstract
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, while a microsomal NADPH dependent Bz nitroreductase activity was found, which was mediated by P450 reductase. No ultrastructurally observable Bz deleterious effects were detected, in contrast to the cardiac effects previously reported for Nfx. As conclusion, if these drugs were used in chagasic patients, Bz would be less risky to heart function than Nfx, when any cardiopathy is present.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Fundação Oswaldo Cruz
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chagas Disease
dc.subject
Benznidazole
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Nifurtimox
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Nitroreduction
dc.subject.classification
Toxicología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-08-22T13:20:53Z
dc.identifier.eissn
1678-8060
dc.journal.volume
103
dc.journal.number
6
dc.journal.pagination
549-553
dc.journal.pais
Brasil
dc.journal.ciudad
Rio de Janeiro
dc.description.fil
Fil: Montalto, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Bartel, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Rodríguez de Castro, Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.journal.title
Memórias do Instituto Oswaldo Cruz
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/ffcbdm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/S0074-02762008000600007
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