Mostrar el registro sencillo del ítem

dc.contributor.author
Vargas Roig, Laura Maria
dc.contributor.author
Cuello Carrión, Fernando Darío
dc.contributor.author
Fernández-Escobar, Nicolás
dc.contributor.author
Daguerre, Pedro
dc.contributor.author
Leuzzi, Marcela
dc.contributor.author
Ibarra, Jorge
dc.contributor.author
Gago, Francisco E.
dc.contributor.author
Nadin, Silvina Beatriz
dc.contributor.author
Ciocca, Daniel Ramon
dc.date.available
2019-08-21T23:28:01Z
dc.date.issued
2008-06
dc.identifier.citation
Vargas Roig, Laura Maria; Cuello Carrión, Fernando Darío; Fernández-Escobar, Nicolás; Daguerre, Pedro; Leuzzi, Marcela; et al.; Prognostic value of Bcl-2 in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy; Elsevier; Molecular Oncology; 2; 1; 6-2008; 102-111
dc.identifier.issn
1574-7891
dc.identifier.uri
http://hdl.handle.net/11336/81958
dc.description.abstract
We have analyzed the predictive/prognostic value of Bcl-2 protein in breast cancer patients treated with neoadjuvant chemotherapy. One hundred and ten patients were submitted to two different chemotherapeutic regimens: a) 5-fluorouracil, adriamycin or epirubicin, and cyclophosphamide (FAC/FEC) during 2-6 cycles before surgery and 3 or 4 additional cycles of FAC/FEC after surgery (n = 40) and b) doxorubicin (D) 75 mg/m2 or epirubicin (E) 120 mg/m2 during 4 cycles before surgery, and 6 cycles of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) after surgery (n = 70). Bcl-2 expression, evaluated by immunohistochemistry, did not change significantly after chemotherapy and was not related to clinical/pathological response. In FAC/FEC group, Bcl-2 positive expression after chemotherapy correlated with better disease free survival (DFS) and overall survival (OS) (P = 0.008 and P = 0.001). In D/E group, Bcl-2 also correlated with better DFS and OS (P = 0.03 and P = 0.054) in the post-chemotherapy biopsies. An unusual nuclear localization of Bax was observed in some biopsies, but this localization did not correlate with the tumor response or outcome of the patients. We found that a high Bcl-2 expression had no predictive value but had prognostic value in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apoptosis
dc.subject
Bcl-2
dc.subject
Breast Cancer
dc.subject
Doxorubicin
dc.subject
Neoadjuvant Chemotherapy
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Prognostic value of Bcl-2 in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T21:24:52Z
dc.journal.volume
2
dc.journal.number
1
dc.journal.pagination
102-111
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Vargas Roig, Laura Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Fernández-Escobar, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Daguerre, Pedro. Hospital Luis Lagomaggiore, Mendoza; Argentina
dc.description.fil
Fil: Leuzzi, Marcela. Hospital Luis Lagomaggiore, Mendoza; Argentina
dc.description.fil
Fil: Ibarra, Jorge. Centro Oncológico de Integración Regional, Coir Mendoza; Argentina
dc.description.fil
Fil: Gago, Francisco E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Nadin, Silvina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Molecular Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molonc.2008.01.004
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.molonc.2008.01.004


Archivos asociados

 

Comunidades y colecciones

Mostrar el registro sencillo del ítem