Artículo
Activation of PPAR alfa and PPAR beta/delta regulates Sertoli cell metabolism.
Regueira, Mariana
; Riera, Maria Fernanda
; Galardo, Maria Noel Lujan
; Pellizzari, Eliana Herminia
; Cigorraga, Selva Beatriz
; Meroni, Silvina Beatriz






Fecha de publicación:
01/2014
Editorial:
Elsevier Ireland
Revista:
Molecular And Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR a and PPAR b/d activation in Sertoli cells (SC). SC cultures obtained from 20-day-old rats were incubated with WY14643 or GW0742-pharmacological activators of PPAR alfa and PPAR beta/delta respectively. The fatty acid transporter CD36, carnitine palmitoyltransferase 1, long- and medium-chain 3-hydroxyacyl-CoA dehydrogenases mRNA levels were analyzed. An increase in the above-mentioned genes in response to activation of both nuclear receptors was observed. Additionally, PPAR b/d activation increased lactate production as a consequence of increased pyruvate availability by inhibiting the Pyruvate Dehydrogenase Complex. Altogether, these results suggest that in SC, PPAR a activation participates in the regulation of FA metabolism. On the other hand, PPAR b/d activation regulates FA metabolism and lactate production ensuring simultaneously the energetic metabolism for SC and germ cells.
Archivos asociados
http://www.sciencedirect.com/science/article/pii/S0303720713004462
http://dx.doi.org/10.1016/j.mce.2013.10.006
http://dx.doi.org/10.1016/j.mce.2013.10.006

Citación:
Regueira, Mariana; Riera, Maria Fernanda; Galardo, Maria Noel Lujan; Pellizzari, Eliana Herminia; Cigorraga, Selva Beatriz; et al.; Activation of PPAR alfa and PPAR beta/delta regulates Sertoli cell metabolism.; Elsevier Ireland; Molecular And Cellular Endocrinology; 382; 1; 1-2014; 271-281
Comunidades y colecciones
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Articulos(CEDIE) [123]
Articulos de CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"