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dc.contributor.author
Colombero Rivas, Cecilia Edith
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dc.contributor.author
Venara, Marcela Cristina
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dc.contributor.author
Gonzalez, Daniel
dc.contributor.author
Roman, Richard J.
dc.contributor.author
Nowicki, Susana
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dc.date.available
2016-11-14T17:59:09Z
dc.date.issued
2014-06
dc.identifier.citation
Colombero Rivas, Cecilia Edith; Venara, Marcela Cristina; Gonzalez, Daniel; Roman, Richard J.; Nowicki, Susana; Cytochrome P4504A inhibitors attenuate the exaggerated natriuretic response to volume expansion in thyroidectomized rats; APS; Physiological Reports; 2; 6; 6-2014; 1-12
dc.identifier.issn
2051-817X
dc.identifier.uri
http://hdl.handle.net/11336/8188
dc.description.abstract
Thyroidectomy augments the natriuretic response to volume expansion; however, the mechanism remains unknown. This study assessed the role of 20-hydroxyeicosatetraenoic acid (20-HETE) in the natriuretic response to an acute volume expansion in hypothyroid rats. Urine flow (1.9-fold), sodium excretion (2.4-fold), fractional sodium excretion (3.8-fold), and distal delivery of sodium (4.1-fold) increased to a greater extent in thyroidectomized rats (TX) than in sham-operated controls (SHAM) following i.v. infusion of isotonic saline (5% body weight) over 60 min. This was associated with inhibition of both proximal and distal tubular reabsorption of sodium. Administration of two mechanistic and chemical dissimilar inhibitors of the synthesis of 20- HETE, 1-aminobenzotriazole (ABT), and N-hydroxy-N?-(-4-butyl-2-methylphenyl) formamidine (HET0016) decreased the natriuretic response in TX rats. Glomerular filtration rate was lower in TX than in SHAM rats and was not altered by the CYP4A inhibitors. The expression, intrarenal distribution, and the formation of 20-HETE and expoxygenase metabolites of arachidonic acid were similar in the cortex and medulla of SHAM and TX rats. These results suggest that CYP4A-derived metabolites of arachidonic acid play an important role in the enhanced natriuretic response to volume expansion in hypothyroid rats even though TX did not alter the expression or activity of these enzymes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
APS
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
20-Hete
dc.subject
Cytochrome P450-4a
dc.subject
Eicosanoids
dc.subject
Hypothyroidism
dc.subject
Sodium Excretion
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Cytochrome P4504A inhibitors attenuate the exaggerated natriuretic response to volume expansion in thyroidectomized rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-11T15:12:11Z
dc.journal.volume
2
dc.journal.number
6
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Colombero Rivas, Cecilia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Venara, Marcela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Gonzalez, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Roman, Richard J.. University Of Mississippi; Estados Unidos
dc.description.fil
Fil: Nowicki, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.journal.title
Physiological Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://physreports.physiology.org/content/2/6/e12040
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208633/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.14814/phy2.12040
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