Mostrar el registro sencillo del ítem
dc.contributor.author
Kikuti, Mariana
dc.contributor.author
Tauro, Laura Beatriz
dc.contributor.author
Moreira, Patrícia S. S.
dc.contributor.author
Campos, Gúbio S.
dc.contributor.author
Paploski, Igor A. D.
dc.contributor.author
Weaver, Scott C.
dc.contributor.author
Reis, Mitermayer G.
dc.contributor.author
Kitron, Uriel D.
dc.contributor.author
Ribeiro, Guilherme S.
dc.date.available
2019-08-12T18:08:59Z
dc.date.issued
2018-07
dc.identifier.citation
Kikuti, Mariana; Tauro, Laura Beatriz; Moreira, Patrícia S. S.; Campos, Gúbio S.; Paploski, Igor A. D.; et al.; Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection; BioMed Central; Virology Journal; 15; 1; 7-2018; 1-7
dc.identifier.issn
1743-422X
dc.identifier.uri
http://hdl.handle.net/11336/81470
dc.description.abstract
Background: Serologic detection of Zika virus (ZIKV) infections is challenging because of antigenic similarities among flaviviruses. Objective: To evaluate the sensitivity and specificity of commercial ZIKV IgM and IgG enzyme-linked immunoassay (ELISA) kits. Methods: We used sera from febrile patients with RT-PCR-confirmed ZIKV infection to determine sensitivity and sera from RT-PCR-confirmed dengue cases and blood donors, both of which were collected before ZIKV epidemics in Brazil (2009-2011 and 2013, respectively) to determine specificity. Results: The ZIKV IgM-ELISA positivity among RT-PCR ZIKV confirmed cases was 0.0% (0/14) and 12.5% (1/8) for acute- and convalescent-phase sera, respectively, while its specificity was 100.0% (58/58) and 98.3% (58/59) for acute- and convalescent-phase sera of dengue patients, and 100.0% (23/23) for blood donors. The ZIKV IgG-ELISA sensitivity was 100.0% (6/6) on convalescent-phase sera from RT-PCR confirmed ZIKV patients, while its specificity was 27.3% (15/55) on convalescent-phase sera from dengue patients and 45.0% (9/20) on blood donors' sera. The ZIKV IgG-ELISA specificity among dengue confirmed cases was much greater among patients with primary dengue (92.3%; 12/13), compared to secondary dengue (7.1%; 3/42). Conclusions: In a setting of endemic dengue transmission, the ZIKV IgM-ELISA had high specificity, but poor sensitivity. In contrast, the ZIKV IgG-ELISA showed low specificity, particularly for patients previously exposed to dengue infections. This suggests that this ZIKV IgM-ELISA is not useful in confirming a diagnosis of ZIKV infection in suspected patients, whereas the IgG-ELISA is more suitable for ZIKV diagnosis among travelers, who reside in areas free of flavivirus transmission, rather than for serosurveys in dengue-endemic areas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enzyme-Linked Immunosorbent Assay
dc.subject
Immunoglobulin G
dc.subject
Immunoglobulin M
dc.subject
Sensitivity And Specificity
dc.subject
Zika Virus
dc.subject.classification
Virología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-08-08T19:09:13Z
dc.journal.volume
15
dc.journal.number
1
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Kikuti, Mariana. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
dc.description.fil
Fil: Tauro, Laura Beatriz. Fundación Oswaldo Cruz; Brasil. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina
dc.description.fil
Fil: Moreira, Patrícia S. S.. Fundación Oswaldo Cruz; Brasil
dc.description.fil
Fil: Campos, Gúbio S.. Universidade Federal da Bahia; Brasil
dc.description.fil
Fil: Paploski, Igor A. D.. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
dc.description.fil
Fil: Weaver, Scott C.. Ut Medical Branch At Galveston;
dc.description.fil
Fil: Reis, Mitermayer G.. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
dc.description.fil
Fil: Kitron, Uriel D.. Fundación Oswaldo Cruz; Brasil. University of Emory; Estados Unidos
dc.description.fil
Fil: Ribeiro, Guilherme S.. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
dc.journal.title
Virology Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://virologyj.biomedcentral.com/articles/10.1186/s12985-018-1015-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12985-018-1015-6
Archivos asociados