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dc.contributor.author
Kikuti, Mariana
dc.contributor.author
Tauro, Laura Beatriz
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dc.contributor.author
Moreira, Patrícia S. S.
dc.contributor.author
Campos, Gúbio S.
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Paploski, Igor A. D.
dc.contributor.author
Weaver, Scott C.
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Reis, Mitermayer G.
dc.contributor.author
Kitron, Uriel D.
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dc.contributor.author
Ribeiro, Guilherme S.
dc.date.available
2019-08-12T18:08:59Z
dc.date.issued
2018-07
dc.identifier.citation
Kikuti, Mariana; Tauro, Laura Beatriz; Moreira, Patrícia S. S.; Campos, Gúbio S.; Paploski, Igor A. D.; et al.; Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection; BioMed Central; Virology Journal; 15; 1; 7-2018; 1-7
dc.identifier.issn
1743-422X
dc.identifier.uri
http://hdl.handle.net/11336/81470
dc.description.abstract
Background: Serologic detection of Zika virus (ZIKV) infections is challenging because of antigenic similarities among flaviviruses. Objective: To evaluate the sensitivity and specificity of commercial ZIKV IgM and IgG enzyme-linked immunoassay (ELISA) kits. Methods: We used sera from febrile patients with RT-PCR-confirmed ZIKV infection to determine sensitivity and sera from RT-PCR-confirmed dengue cases and blood donors, both of which were collected before ZIKV epidemics in Brazil (2009-2011 and 2013, respectively) to determine specificity. Results: The ZIKV IgM-ELISA positivity among RT-PCR ZIKV confirmed cases was 0.0% (0/14) and 12.5% (1/8) for acute- and convalescent-phase sera, respectively, while its specificity was 100.0% (58/58) and 98.3% (58/59) for acute- and convalescent-phase sera of dengue patients, and 100.0% (23/23) for blood donors. The ZIKV IgG-ELISA sensitivity was 100.0% (6/6) on convalescent-phase sera from RT-PCR confirmed ZIKV patients, while its specificity was 27.3% (15/55) on convalescent-phase sera from dengue patients and 45.0% (9/20) on blood donors' sera. The ZIKV IgG-ELISA specificity among dengue confirmed cases was much greater among patients with primary dengue (92.3%; 12/13), compared to secondary dengue (7.1%; 3/42). Conclusions: In a setting of endemic dengue transmission, the ZIKV IgM-ELISA had high specificity, but poor sensitivity. In contrast, the ZIKV IgG-ELISA showed low specificity, particularly for patients previously exposed to dengue infections. This suggests that this ZIKV IgM-ELISA is not useful in confirming a diagnosis of ZIKV infection in suspected patients, whereas the IgG-ELISA is more suitable for ZIKV diagnosis among travelers, who reside in areas free of flavivirus transmission, rather than for serosurveys in dengue-endemic areas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enzyme-Linked Immunosorbent Assay
dc.subject
Immunoglobulin G
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Immunoglobulin M
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Sensitivity And Specificity
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Zika Virus
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Virología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-08-08T19:09:13Z
dc.journal.volume
15
dc.journal.number
1
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Kikuti, Mariana. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
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Fil: Tauro, Laura Beatriz. Fundación Oswaldo Cruz; Brasil. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina
dc.description.fil
Fil: Moreira, Patrícia S. S.. Fundación Oswaldo Cruz; Brasil
dc.description.fil
Fil: Campos, Gúbio S.. Universidade Federal da Bahia; Brasil
dc.description.fil
Fil: Paploski, Igor A. D.. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
dc.description.fil
Fil: Weaver, Scott C.. Ut Medical Branch At Galveston;
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Fil: Reis, Mitermayer G.. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
dc.description.fil
Fil: Kitron, Uriel D.. Fundación Oswaldo Cruz; Brasil. University of Emory; Estados Unidos
dc.description.fil
Fil: Ribeiro, Guilherme S.. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
dc.journal.title
Virology Journal
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://virologyj.biomedcentral.com/articles/10.1186/s12985-018-1015-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12985-018-1015-6
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