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Artículo

Overexpression of the Insulin-like growth factor 1 receptor (IGF-1R) is associated with malignancy in familial pheochromocytomas and paragangliomas

Fernández, María CeliaIcon ; Martin, AyelenIcon ; Venara, Marcela CristinaIcon ; Calcagno, María Lujan; Sanso, Gabriela; Quintana, SilvinaIcon ; Chemes, Hector EdgardoIcon ; Barontini, Marta BeatrizIcon ; Pennisi, Patricia AlejandraIcon
Fecha de publicación: 03/2013
Editorial: Wiley
Revista: Clinical Endocrinology
ISSN: 0300-0664
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Endocrinología y Metabolismo

Resumen

CONTEXT: Pheochromocytomas and paragangliomas (pheo/pgl) are neuroendocrine tumours derived from chromaffin cells. Although mostly benign, up to 26% of pheo/pgl will undergo malignant transformation. Reliable histological signs to differentiate benign pheo/pgl from malignant tumours are currently lacking. Increased IGF-1R expression has been shown during progression to metastatic phenotypes of several types of cancer. OBJECTIVE: To analyse the distribution and expression of the IGF-1R in pheo/pgl of different genetic origin and degree of malignancy. MEASUREMENTS: We studied the expression of the IGF-1R protein by immunohistochemistry, in 40 primary tumours from patients with pheo/pgl from different genetic aetiology (11 of 29 metastatic/nonmetastatic diseases). RESULTS: We found a strong association between increased expression of IGF-1R and malignant behaviour regardless of the age at diagnosis and the genetic aetiology. IGF-1R labelling was mostly weak in primary tumours from patients with nonmetastatic pheo/pgl. Conversely, intense IGF-1R labelling was predominant in cases of pheo/pgl with confirmed metastatic disease. The risk of metastases was 11·7 times higher if tumour IGF-1R labelling was intense independently of age at diagnosis. The probability of remaining free of metastases was higher in patients with pheo/pgl scored weak for IGF-1R at 60 months and more than twofold higher at 120 months of follow-up than in patients with intense IGF-1R labelling in their primary tumours. CONCLUSIONS: Our results strongly suggest that IGF-1R is associated with malignancy in familial pheo/pgl and that IGF-1R expression in the primary tumour might be a useful tool to detect those patients harbouring pheo/pgl who have an increased risk of metastasis.
Palabras clave: Igf-1 Receptor , Pheochromocytoma , Paraganglioma , Metastasis , Immunohistochemistry
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/8146
URL: http://onlinelibrary.wiley.com/doi/10.1111/cen.12205/abstract
DOI: http://dx.doi.org/10.1111/cen.12205
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Articulos(CEDIE)
Articulos de CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Citación
Fernández, María Celia; Martin, Ayelen; Venara, Marcela Cristina; Calcagno, María Lujan; Sanso, Gabriela; et al.; Overexpression of the Insulin-like growth factor 1 receptor (IGF-1R) is associated with malignancy in familial pheochromocytomas and paragangliomas; Wiley; Clinical Endocrinology; 79; 5; 3-2013; 623-630
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