Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Hypogonadotropic Hypogonadism in Infants with Congenital Hypopituitarism: A Challenge toDiagnose at an Early Stage

Braslavsky, Debora; Grinspon, RominaIcon ; Ballerini, Maria Gabriela; Bedecarras, Patricia GladysIcon ; Loreti, Nazareth; Gabriela, Bastida; Ropelato, Maria G.; Keselman, Ana; Campo, Stella MarisIcon ; Rey, Rodolfo AlbertoIcon ; Bergada, Ignacio
Fecha de publicación: 09/2015
Editorial: Karger
Revista: Hormone Research in paediatrics
ISSN: 1663-2818
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Endocrinología y Metabolismo

Resumen

Background: Combined pituitary hormone deficiency (CPHD) presents a wide spectrum of pituitary gland disorders. The postnatal gonadotropic surge provides a useful period to explore the gonadotropic axis for assessing the presence of congenital hypogonadotropic hypogonadism (CHH). Aim: To explore the functioning of the hypothalamic-pituitary-gonadal axis in the postnatal gonadotropic surge for an early diagnosis of CHH in newborns or infants suspected of having CPHD. Subjects and Methods: A cohort of 27 boys under 6 months and 19 girls under 24 months of age with suspected hypopituitarism was studied. Serum concentrations of LH, FSH, testosterone, inhibin B, anti-Müllerian hormone (AMH) and estradiol were measured, and male external genitalia were characterized as normal or abnormal (micropenis, microorchidism and/or cryptorchidism). Results: CPHD was confirmed in 36 out of 46 patients. Low LH and testosterone levels were found in 66% of the hypopituitary males, in significant association with the presence of abnormal external genitalia. This abnormality had a positive predictive value of 93% for CHH. No significant association was observed between serum FSH, AMH and inhibin B and the patient's external genitalia. Conclusion: In newborn or infant boys with CPHD, LH and testosterone concentrations measured throughout the postnatal gonadotropic surge, together with a detailed evaluation of the external genital phenotype, facilitate the diagnosis of CHH at an early stage.
Palabras clave: Hypogonadotrophic Hypogonadism , Sertoli Cell , Gonadotrophins
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 470.8Kb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/8144
URL: http://www.karger.com/Article/Abstract/439051
DOI: http://dx.doi.org/10.1159/000439051
Colecciones
Articulos(CEDIE)
Articulos de CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"
Citación
Braslavsky, Debora; Grinspon, Romina; Ballerini, Maria Gabriela; Bedecarras, Patricia Gladys; Loreti, Nazareth; et al.; Hypogonadotropic Hypogonadism in Infants with Congenital Hypopituitarism: A Challenge toDiagnose at an Early Stage; Karger; Hormone Research in paediatrics; 84; 5; 9-2015; 289-297
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES