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dc.contributor.author
del Rey, Graciela Monica
dc.contributor.author
Venara, Marcela Cristina
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Papendieck, P.
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Gruñeiro, L.
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Tangari, A.
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Boywitt, A.
dc.contributor.author
Casali, B.
dc.contributor.author
Laudicina, A.
dc.date.available
2016-11-10T20:29:41Z
dc.date.issued
2015-02
dc.identifier.citation
del Rey, Graciela Monica; Venara, Marcela Cristina; Papendieck, P.; Gruñeiro, L.; Tangari, A.; et al.; Association of Distal Deletion of the Short arm of Chromosome 9 with 46,XY Disorder of Sex Development and Gonadoblastoma; Biological Systems; Biological Systems; 4; 1; 2-2015; 129
dc.identifier.issn
2329-6577
dc.identifier.uri
http://hdl.handle.net/11336/8139
dc.description.abstract
Deletion of the short arm of chromosome 9 is associated with two distinct clinical prototypes. Small telomeric distal 9p deletions have been reported in patients 46,XY with gonadal dysgenesis, this region contains genes required in two copies for normal testis development. Recent studies have narrowed the interval 9p24.3-pter containing the putative autosomal testis-determining gene(s) known as domain DMRT. On the other hand, and depending on the extent of deletion of the short arm, the clinical characteristics of monosomy 9p syndrome may emerge. We present an infant female with complete 46,XY gonadal dysgenesis, who was examined for motor developmental retardation. In the karyotype a chromosomal deletion 9p24.1 was identified by cytogenetic and fluorescence in situ hybridization studies. No SRY deletion or mutation was detected. Ultrasonographic studies showed a normal uterus. Basal luteinizing hormone and follicle stimulating hormone values were high. The patient underwent gonadectomy at 3.2 years of age, and histologic analysis disclosed dysgenetic gonads with gonadoblastoma.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Biological Systems
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Distal Monosomy 9p Chromosome
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9p Partial Deletion
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Disorders of Sexual Development (Dsd))
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Gonadal Dysgenesis
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Fluorescence in Situ Hybridization (Fish)
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Gonadoblastoma
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Dmrt Genes
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Endocrinología y Metabolismo
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Association of Distal Deletion of the Short arm of Chromosome 9 with 46,XY Disorder of Sex Development and Gonadoblastoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-10T13:51:13Z
dc.journal.volume
4
dc.journal.number
1
dc.journal.pagination
129
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: del Rey, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
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Fil: Venara, Marcela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Papendieck, P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Gruñeiro, L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Tangari, A.. Fundación Hospitalaria; Argentina
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Fil: Boywitt, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Casali, B.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Laudicina, A.. Lexel SRL.; Argentina
dc.journal.title
Biological Systems
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.omicsgroup.org/journals/association-of-distal-deletion-of-the-short-arm-of-chromosome-9-with-46xy-disorder-of-sex-development-and-gonadoblastoma-2329-6577-1000129.php?aid=45515
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2329-6577.1000129
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