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dc.contributor.author
Rovsing, Louise
dc.contributor.author
Clokie, Samuel
dc.contributor.author
Bustos, Diego Martin
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dc.contributor.author
Rohde, Kristian
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Coon, Steven L.
dc.contributor.author
Litman, Thomas
dc.contributor.author
Rath, Martin F.
dc.contributor.author
Møller, Morten
dc.contributor.author
Klein, David C.
dc.date.available
2019-08-09T19:19:11Z
dc.date.issued
2011-10
dc.identifier.citation
Rovsing, Louise; Clokie, Samuel; Bustos, Diego Martin; Rohde, Kristian; Coon, Steven L.; et al.; Crx broadly modulates the pineal transcriptome; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 119; 2; 10-2011; 262-274
dc.identifier.issn
0022-3042
dc.identifier.uri
http://hdl.handle.net/11336/81345
dc.description.abstract
Cone-rod homeobox (Crx) encodes Crx, a transcription factor expressed selectively in retinal photoreceptors and pinealocytes, the major cell type of the pineal gland. In this study, the influence of Crx on the mammalian pineal gland was studied by light and electron microscopy and by use of microarray and qRTPCR technology, thereby extending previous studies on selected genes (Furukawa 1999). Deletion of Crx was not found to alter pineal morphology, but was found to broadly modulate the mouse pineal transcriptome, characterized by a > 2-fold down-regulation of 543 genes and a > 2-fold up-regulation of 745 genes (p < 0.05). Of these, one of the most highly up-regulated (18-fold) was Hoxc4, a member of the Hox gene family, members of which are known to control gene expression cascades. During a 24-h period, a set of 51 genes exhibited differential day/night expression in pineal glands of wild-type animals; only eight of these were also day/night expressed in the Crx -/- pineal gland. However, in the Crx-/- pineal gland 41 genes exhibited differential night/day expression that was not seen in wild-type animals. These findings indicate that Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue. Some effects of Crx deletion on the pineal transcriptome might be mediated by Hoxc4 up-regulation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Crx
dc.subject
Gene Expression
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Hoxc4
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Microarray
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Pineal Gland
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Transcriptome Profiling
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Crx broadly modulates the pineal transcriptome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-08-01T14:39:14Z
dc.journal.volume
119
dc.journal.number
2
dc.journal.pagination
262-274
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Rovsing, Louise. Universidad de Copenhagen; Dinamarca. National Instituto of Child Health & Human Development; Estados Unidos
dc.description.fil
Fil: Clokie, Samuel. National Instituto of Child Health & Human Development; Estados Unidos
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Fil: Bustos, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Instituto of Child Health & Human Development; Estados Unidos
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Fil: Rohde, Kristian. Universidad de Copenhagen; Dinamarca
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Fil: Coon, Steven L.. National Instituto of Child Health & Human Development; Estados Unidos
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Fil: Litman, Thomas. Universidad de Copenhagen; Dinamarca
dc.description.fil
Fil: Rath, Martin F.. Universidad de Copenhagen; Dinamarca
dc.description.fil
Fil: Møller, Morten. Universidad de Copenhagen; Dinamarca
dc.description.fil
Fil: Klein, David C.. National Instituto of Child Health & Human Development; Estados Unidos
dc.journal.title
Journal of Neurochemistry
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1471-4159.2011.07405.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2011.07405.x
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