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dc.contributor.author
Grinspon, Romina
dc.contributor.author
Rey, Rodolfo Alberto
dc.date.available
2016-11-10T18:03:16Z
dc.date.issued
2014-12
dc.identifier.citation
Grinspon, Romina; Rey, Rodolfo Alberto; When Hormone Defects Cannot Explain It: Malformative Disorders of Sex Development; Wiley; Birth Defects Research Part C-embryo Today-reviews; 102; 4; 12-2014; 359-373
dc.identifier.issn
1542-975X
dc.identifier.uri
http://hdl.handle.net/11336/8129
dc.description.abstract
The birth of a baby with malformations of the genitalia urges medical action. Even in cases where the condition is not life-threatening, the identification of the external genitalia as male or female is emotionally essential for the family, and genital malformations represent one of the most stressful situations around a newborn. The female or male configuration of the genitalia normally evolves during fetal life according to the genetic, gonadal, and hormonal sex. Disorders of sex development occur when male hormone (androgens and anti-Müllerian hormone) secretion or action is insufficient in the 46,XY fetus or when there is an androgen excess in the 46,XX fetus. However, sex hormone defects during fetal development cannot explain all congenital malformations of the reproductive tract. This review is focused on those congenital conditions in which gonadal function and sex hormone target organ sensitivity are normal and, therefore, not responsible for the genital malformation. Furthermore, because the reproductive and urinary systems share many common pathways in embryo-fetal development, conditions associating urogenital malformations are discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Desorders of Sex Development
dc.subject
Malformative Dsd
dc.subject
Dsd
dc.subject.classification
Endocrinología y Metabolismo
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
When Hormone Defects Cannot Explain It: Malformative Disorders of Sex Development
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-10T13:50:41Z
dc.journal.volume
102
dc.journal.number
4
dc.journal.pagination
359-373
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Birth Defects Research Part C-embryo Today-reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/bdrc.21086/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1002/bdrc.21086
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