Artículo
CNS drug development: Lost in translation?
Talevi, Alan
; Bellera, Carolina Leticia
; Di Ianni, Mauricio Emiliano
; Gantner, Melisa Edith
; Bruno Blanch, Luis Enrique; Castro, Eduardo Alberto
Fecha de publicación:
09/2012
Editorial:
Bentham Science Publishers
Revista:
Mini-reviews In Medicinal Chemistry
ISSN:
1389-5575
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
CNS drug development is characterized by an especially high attrition rate, despite clear unmet medical needs in the field of neuro-pharmacology and significant investment in R&D of novel CNS drug treatments. Here, we overview the issues underlying the intrinsic difficulty of CNS drugs development, including obstacles of pharmacokinetic nature and lack of predictivity of preclinical tests. We highlight current efforts to overcome these limitations, with an emphasis on modeling opportunities towards early recognition of CNS candidates (stressing the possibilities of multi-target directed ligands or "magic shotguns") and different approaches to improve CNS bioavailability.
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Talevi, Alan; Bellera, Carolina Leticia; Di Ianni, Mauricio Emiliano; Gantner, Melisa Edith; Bruno Blanch, Luis Enrique; et al.; CNS drug development: Lost in translation?; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 12; 10; 9-2012; 959-970
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