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dc.contributor.author
Barbisan, Gisela
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Perez, Luis Orlando
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Difranza, L
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Fernandez, Cintia Judith
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Ciancio, Noelia Esther
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Golijow, Carlos Daniel
dc.date.available
2019-08-05T20:54:17Z
dc.date.issued
2011-03
dc.identifier.citation
Barbisan, Gisela; Perez, Luis Orlando; Difranza, L; Fernandez, Cintia Judith; Ciancio, Noelia Esther; et al.; XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women; I R O G Canada, Inc; European Journal Of Gynaecological Oncology; 32; 3; 3-2011; 274-279
dc.identifier.issn
0392-2936
dc.identifier.uri
http://hdl.handle.net/11336/80944
dc.description.abstract
Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the base excesion repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materia and Methods: we conducted a case control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associatted with a decreased risk for cervical carcinoma. Conclusions: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
I R O G Canada, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cervical Cancer
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Hpv
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Single Nucleotide Polymorphism
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Xrcc1
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-11T21:15:18Z
dc.journal.volume
32
dc.journal.number
3
dc.journal.pagination
274-279
dc.journal.pais
Canadá
dc.journal.ciudad
Vancouver
dc.description.fil
Fil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
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Fil: Difranza, L. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Fernandez, Cintia Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil
Fil: Ciancio, Noelia Esther. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Golijow, Carlos Daniel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
European Journal Of Gynaecological Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.irog.net/ejgo
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