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dc.contributor.author
Heinecke, Julie L.
dc.contributor.author
Khin, Chousu
dc.contributor.author
Melo Pereira, Jose Clayston
dc.contributor.author
Suarez, Sebastian
dc.contributor.author
Iretskii, Alexei V.
dc.contributor.author
Doctorovich, Fabio
dc.contributor.author
Ford, Peter C.
dc.date.available
2016-11-08T21:43:46Z
dc.date.issued
2013-02-19
dc.identifier.citation
Heinecke, Julie L.; Khin, Chousu; Melo Pereira, Jose Clayston; Suarez, Sebastian; Iretskii, Alexei V.; et al.; Nitrite Reduction Mediated by Heme Models. Routes to NO and HNO?; American Chemical Society; Journal Of The American Chemical Society; 135; 10; 19-2-2013; 4007-4017
dc.identifier.issn
0002-7863
dc.identifier.uri
http://hdl.handle.net/11336/8079
dc.description.abstract
The water-soluble ferriheme model Fe(III)(TPPS) mediates oxygen atom transfer from inorganic nitrite to a water-soluble phosphine (tppts), dimethyl sulfide, and the biological thiols cysteine (CysSH) and glutathione (GSH). The products with the latter reductant are the respective sulfenic acids CysS(O)H and GS(O)H, although these reactive intermediates are rapidly trapped by reaction with excess thiol. The nitrosyl complex Fe(II)(TPPS)(NO) is the dominant iron species while excess substrate is present. However, in slightly acidic media (pH ≈ 6), the system does not terminate at this very stable ferrous nitrosyl. Instead, it displays a matrix of redox transformations linking spontaneous regeneration of Fe(III)(TPPS) to the formation of both N2O and NO. Electrochemical sensor and trapping experiments demonstrate that HNO (nitroxyl) is formed, at least when tppts is the reductant. HNO is the likely predecessor of the N2O. A key pathway to NO formation is nitrite reduction by Fe(II)(TPPS), and the kinetics of this iron-mediated transformation are described. Given that inorganic nitrite has protective roles during ischemia/reperfusion (I/R) injury to organs, attributed in part to NO formation, and that HNO may also reduce net damage from I/R, the present studies are relevant to potential mechanisms of such nitrite protection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nitrite
dc.subject
Heme
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Nitroxyl
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Iron
dc.subject.classification
Química Inorgánica y Nuclear
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Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Nitrite Reduction Mediated by Heme Models. Routes to NO and HNO?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-10-25T19:27:54Z
dc.journal.volume
135
dc.journal.number
10
dc.journal.pagination
4007-4017
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Heinecke, Julie L.. University Of California At Santa Barbara; Estados Unidos
dc.description.fil
Fil: Khin, Chousu. University Of California At Santa Barbara; Estados Unidos
dc.description.fil
Fil: Melo Pereira, Jose Clayston. University Of California At Santa Barbara; Estados Unidos
dc.description.fil
Fil: Suarez, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Iretskii, Alexei V.. Lake Superior State University; Estados Unidos. University Of California At Santa Barbara; Estados Unidos
dc.description.fil
Fil: Doctorovich, Fabio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Ford, Peter C.. University Of California At Santa Barbara; Estados Unidos
dc.journal.title
Journal Of The American Chemical Society
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/dx.doi.org/10.1021/ja312092x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ja312092x
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