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dc.contributor.author
Arcos Burgos, M.
dc.contributor.author
Jain, M.
dc.contributor.author
Acosta, M. T.
dc.contributor.author
Shively, S.
dc.contributor.author
Stanescu, H.
dc.contributor.author
Wallis, D.
dc.contributor.author
Domene, Sabina
dc.contributor.author
Vélez, J .I.
dc.contributor.author
Karkera, J. D.
dc.contributor.author
Balog, J.
dc.contributor.author
Berg, K.
dc.contributor.author
Kleta, R.
dc.contributor.author
Gahl, W. A.
dc.contributor.author
Roessler, E.
dc.contributor.author
Long, R.
dc.contributor.author
Lie, J.
dc.contributor.author
Pineda, D.
dc.contributor.author
Londoño, A. C.
dc.contributor.author
Palacio, J. D.
dc.contributor.author
Arbelaez, A.
dc.contributor.author
Lopera, F.
dc.contributor.author
Elia, J.
dc.contributor.author
Hakonarson, H.
dc.contributor.author
Johansson, S.
dc.contributor.author
Knappskog, P. M.
dc.contributor.author
Haavik, J.
dc.contributor.author
Ribases, M.
dc.contributor.author
Cormand, B.
dc.contributor.author
Bayes, M.
dc.contributor.author
Casas, M.
dc.contributor.author
Ramos Quiroga, J. A.
dc.contributor.author
Hervas, A.
dc.contributor.author
Maher, B. S.
dc.contributor.author
Faraone, S. V.
dc.contributor.author
Seitz, C.
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Freitag, C. M.
dc.contributor.author
Palmason, H.
dc.contributor.author
Meyer, J.
dc.contributor.author
Romanos, M.
dc.contributor.author
Walitza, S.
dc.contributor.author
Hemminger, U.
dc.contributor.author
Warnke, A.
dc.contributor.author
Romanos, J.
dc.contributor.author
Renner, T.
dc.contributor.author
Jacob, C.
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Lesch, K. P.
dc.contributor.author
Swanson, J.
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Vortmeyer, A.
dc.contributor.author
Bailey Wilson, J. E.
dc.contributor.author
Castellanos, F. X.
dc.contributor.author
Muenke, M.
dc.date.available
2019-07-29T19:06:55Z
dc.date.issued
2010-11
dc.identifier.citation
Arcos Burgos, M.; Jain, M.; Acosta, M. T.; Shively, S.; Stanescu, H.; et al.; A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication; Nature Publishing Group; Molecular Psychiatry; 15; 11; 11-2010; 1053-1066
dc.identifier.issn
1359-4184
dc.identifier.uri
http://hdl.handle.net/11336/80502
dc.description.abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started with a linkage study based on large multigenerational families in a population isolate, followed by fine mapping of targeted regions using a family-based design. Family- and population-based association studies in five samples from disparate regions of the world were used for replication. Brain imaging studies were performed to evaluate gene function. The linkage study discovered a genome region harbored in the Latrophilin 3 gene (LPHN3). In the world-wide samples (total n6360, with 2627 ADHD cases and 2531 controls) statistical association of LPHN3 and ADHD was confirmed. Functional studies revealed that LPHN3 variants are expressed in key brain regions related to attention and activity, affect metabolism in neural circuits implicated in ADHD, and are associated with response to stimulant medication. Linkage and replicated association of ADHD with a novel non-candidate gene (LPHN3) provide new insights into the genetics, neurobiology, and treatment of ADHD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adhd
dc.subject
Complex Trait
dc.subject
Gene
dc.subject
Genetics
dc.subject
Latrophilin
dc.subject
Lphn3
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-10T19:05:15Z
dc.journal.volume
15
dc.journal.number
11
dc.journal.pagination
1053-1066
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Arcos Burgos, M.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Jain, M.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Acosta, M. T.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Shively, S.. National Human Genome Research Institute; Estados Unidos. National Institute Of Neurological Disorders And Stroke; Estados Unidos
dc.description.fil
Fil: Stanescu, H.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Wallis, D.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Domene, Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Vélez, J .I.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Karkera, J. D.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Balog, J.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Berg, K.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Kleta, R.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Gahl, W. A.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Roessler, E.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Long, R.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Lie, J.. National Institute Of Neurological Disorders And Stroke; Estados Unidos
dc.description.fil
Fil: Pineda, D.. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Londoño, A. C.. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Palacio, J. D.. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Arbelaez, A.. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Lopera, F.. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Elia, J.. The Children's Hospital Of Philadelphia; Estados Unidos
dc.description.fil
Fil: Hakonarson, H.. The Children's Hospital Of Philadelphia; Estados Unidos
dc.description.fil
Fil: Johansson, S.. University Of Bergen; Noruega
dc.description.fil
Fil: Knappskog, P. M.. University Of Bergen; Noruega
dc.description.fil
Fil: Haavik, J.. University Of Bergen; Noruega
dc.description.fil
Fil: Ribases, M.. Hospital Universitari Vall D'hebron; España
dc.description.fil
Fil: Cormand, B.. Universidad de Barcelona; España
dc.description.fil
Fil: Bayes, M.. Universidad de Barcelona; España
dc.description.fil
Fil: Casas, M.. Universitat Autònoma de Barcelona; España. Hospital Universitari Vall D'hebron; España
dc.description.fil
Fil: Ramos Quiroga, J. A.. Universitat Autònoma de Barcelona; España. Hospital Universitari Vall D'hebron; España
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Fil: Hervas, A.. Hospital Mutua de Terrassa; España
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Fil: Maher, B. S.. Virginia Institute For Psychiatric And Behavioral Genetics; Estados Unidos
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Fil: Faraone, S. V.. State University Of New York Upstate Medical University; Estados Unidos
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Fil: Seitz, C.. Saarland University Hospital; Alemania
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Fil: Freitag, C. M.. Saarland University Hospital; Alemania
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Fil: Palmason, H.. University of Trier; Alemania
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Fil: Meyer, J.. University of Trier; Alemania
dc.description.fil
Fil: Romanos, M.. Universität Würzburg; Alemania
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Fil: Walitza, S.. Universität Würzburg; Alemania
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Fil: Hemminger, U.. Universität Würzburg; Alemania
dc.description.fil
Fil: Warnke, A.. Universität Würzburg; Alemania
dc.description.fil
Fil: Romanos, J.. Universität Würzburg; Alemania
dc.description.fil
Fil: Renner, T.. Universität Würzburg; Alemania
dc.description.fil
Fil: Jacob, C.. Universität Würzburg; Alemania
dc.description.fil
Fil: Lesch, K. P.. Universität Würzburg; Alemania
dc.description.fil
Fil: Swanson, J.. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Vortmeyer, A.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Bailey Wilson, J. E.. National Human Genome Research Institute; Estados Unidos
dc.description.fil
Fil: Castellanos, F. X.. University of New York; Estados Unidos
dc.description.fil
Fil: Muenke, M.. National Human Genome Research Institute; Estados Unidos
dc.journal.title
Molecular Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/mp20106
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1038/mp.2010.6
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