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dc.contributor.author
El-Sayed, Najib M.
dc.contributor.author
Myler, Peter J.
dc.contributor.author
Bartholomeu, Daniella C.
dc.contributor.author
Nilsson, Daniel
dc.contributor.author
Aggarwal, Gautam
dc.contributor.author
Tran, Anh-Nhi
dc.contributor.author
Ghedin, Elodie
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Worthey, Elizabeth A.
dc.contributor.author
Delcher, Arthur L.
dc.contributor.author
Blandin, Gaëlle
dc.contributor.author
Westenberger, Scott J.
dc.contributor.author
Caler, Elisabet
dc.contributor.author
Cerqueira, Gustavo C.
dc.contributor.author
Branche, Carole
dc.contributor.author
Haas, Brian
dc.contributor.author
Anupama, Atashi
dc.contributor.author
Arner, Erik
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Åslund, Lena
dc.contributor.author
Attipoe, Philip
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Bontempi, Esteban
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Bringaud, Frédéric
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Burton, Peter
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Cadag, Eithon
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Campbell, David A.
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Carrington, Mark
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Crabtree, Jonathan
dc.contributor.author
Darban, Hamid
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Da Silveira, Jose Franco
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De Jong, Pieter
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Edwards, Kimberly
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Englund, Paul T.
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Fazelina, Gholam
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Feldblyum, Tamara
dc.contributor.author
Ferella, Marcela
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Frasch, Alberto Carlos C.
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Gull, Keith
dc.contributor.author
Horn, David
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Hou, Lihua
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Huang, Yiting
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Kindlund, Ellen
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Klingbeil, Michele
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Kluge, Sindy
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Koo, Hean
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Lacerda, Daniela
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Levin, Mariano Jorge
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Lorenzi, Hernan
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Louie, Tin
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Machado, Carlos Renato
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McCulloch, Richard
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McKenna, Alan
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Mizuno, Yumi
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Mottram, Jeremy C.
dc.contributor.author
Nelson, Siri
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Ochaya, Stephen
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Osoegawa, Kazutoyo
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Pai, Grace
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Parsons, Marilyn
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Pentony, Martin
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Pettersson, Ulf
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Pop, Mihai
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Ramirez, Jose Luis
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Rinta, Joel
dc.contributor.author
Robertson, Laura
dc.contributor.author
Salzberg, Steven L.
dc.contributor.author
Sanchez, Daniel Oscar
dc.contributor.author
Seyler, Amber
dc.contributor.author
Sharma, Reuben
dc.contributor.author
Shetty, Jyoti
dc.contributor.author
Simpson, Anjana J.
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Sisk, Ellen
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Tammi, Martti T.
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Tarleton, Rick
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Teixeira, Santuza
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Van Aken, Susan
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Vogt, Christy
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Ward, Pauline N.
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Wickstead, Bill
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Wortman, Jennifer
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White, Owen
dc.contributor.author
Fraser, Claire M.
dc.contributor.author
Stuart, Kenneth D.
dc.contributor.author
Andersson, Björn
dc.date.available
2019-07-29T18:57:33Z
dc.date.issued
2005-07
dc.identifier.citation
El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; et al.; The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease; American Association for the Advancement of Science; Science; 309; 5733; 7-2005; 409-415
dc.identifier.issn
0036-8075
dc.identifier.uri
http://hdl.handle.net/11336/80500
dc.description.abstract
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association for the Advancement of Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-22T13:16:47Z
dc.journal.volume
309
dc.journal.number
5733
dc.journal.pagination
409-415
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: El-Sayed, Najib M.. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Myler, Peter J.. University of Washington; Estados Unidos. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos
dc.description.fil
Fil: Bartholomeu, Daniella C.. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Nilsson, Daniel. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Aggarwal, Gautam. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Tran, Anh-Nhi. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Ghedin, Elodie. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Worthey, Elizabeth A.. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Delcher, Arthur L.. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Blandin, Gaëlle. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Westenberger, Scott J.. The Institute for Genomic Research; Estados Unidos. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Caler, Elisabet. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Cerqueira, Gustavo C.. The Institute for Genomic Research; Estados Unidos. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Branche, Carole. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Haas, Brian. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Anupama, Atashi. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Arner, Erik. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Åslund, Lena. Uppsala Universitet; Suecia
dc.description.fil
Fil: Attipoe, Philip. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Bontempi, Esteban. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
dc.description.fil
Fil: Bringaud, Frédéric. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Burton, Peter. University of Glasgow; Reino Unido
dc.description.fil
Fil: Cadag, Eithon. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Campbell, David A.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Carrington, Mark. University of Cambridge; Estados Unidos
dc.description.fil
Fil: Crabtree, Jonathan. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Darban, Hamid. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Da Silveira, Jose Franco. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: De Jong, Pieter. Children's Hospital Oakland Research Institute; Estados Unidos
dc.description.fil
Fil: Edwards, Kimberly. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Englund, Paul T.. The Johns Hopkins School Of Medicine; Estados Unidos
dc.description.fil
Fil: Fazelina, Gholam. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Feldblyum, Tamara. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Ferella, Marcela. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Frasch, Alberto Carlos C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Gull, Keith. University of Oxford; Reino Unido
dc.description.fil
Fil: Horn, David. London School of Hygiene and Tropical Medicine; Reino Unido
dc.description.fil
Fil: Hou, Lihua. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Huang, Yiting. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Kindlund, Ellen. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Klingbeil, Michele. University Of Massachusetts; Estados Unidos
dc.description.fil
Fil: Kluge, Sindy. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Koo, Hean. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Lacerda, Daniela. Fundación Oswaldo Cruz; Brasil. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Lorenzi, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Louie, Tin. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Machado, Carlos Renato. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: McCulloch, Richard. University of Glasgow; Reino Unido
dc.description.fil
Fil: McKenna, Alan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Mizuno, Yumi. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Mottram, Jeremy C.. University of Glasgow; Reino Unido
dc.description.fil
Fil: Nelson, Siri. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Ochaya, Stephen. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Osoegawa, Kazutoyo. Children's Hospital Oakland Research Institute; Estados Unidos
dc.description.fil
Fil: Pai, Grace. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Parsons, Marilyn. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos
dc.description.fil
Fil: Pentony, Martin. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Pettersson, Ulf. Uppsala Universitet; Suecia
dc.description.fil
Fil: Pop, Mihai. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Ramirez, Jose Luis. Universidad Central de Venezuela, Facultad de Ciencias; Venezuela
dc.description.fil
Fil: Rinta, Joel. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Robertson, Laura. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Salzberg, Steven L.. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Sanchez, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Seyler, Amber. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Sharma, Reuben. University of Cambridge; Estados Unidos
dc.description.fil
Fil: Shetty, Jyoti. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Simpson, Anjana J.. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Sisk, Ellen. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Tammi, Martti T.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. National University Of Singapore; Singapur
dc.description.fil
Fil: Tarleton, Rick. University of Georgia; Estados Unidos
dc.description.fil
Fil: Teixeira, Santuza. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Van Aken, Susan. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Vogt, Christy. Seattle Biomedical Research Institute; Estados Unidos
dc.description.fil
Fil: Ward, Pauline N.. University of Glasgow; Reino Unido
dc.description.fil
Fil: Wickstead, Bill. Sir William Dunn School Of Pathology; Reino Unido
dc.description.fil
Fil: Wortman, Jennifer. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: White, Owen. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Fraser, Claire M.. The Institute for Genomic Research; Estados Unidos
dc.description.fil
Fil: Stuart, Kenneth D.. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos
dc.description.fil
Fil: Andersson, Björn. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.journal.title
Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/science.1112631
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/309/5733/409


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Mostrar el registro sencillo del ítem