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dc.contributor.author
Cela, Eliana Maiten
dc.contributor.author
Friedrich, Adrián
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Paz, Mariela Laura
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Vanzulli, Silvia
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Leoni, Juliana
dc.contributor.author
Gonzalez Maglio, Daniel Horacio
dc.date.available
2016-11-08T16:23:31Z
dc.date.issued
2014-11
dc.identifier.citation
Cela, Eliana Maiten; Friedrich, Adrián; Paz, Mariela Laura; Vanzulli, Silvia; Leoni, Juliana; et al.; Time-course study of different innate immune mediators produced by ultraviolet irradiated skin. Comparative effects between short and daily versus harmful and imprudent UV- exposures; Wiley; Immunology; 1; 145; 11-2014; 82-93
dc.identifier.issn
0019-2805
dc.identifier.uri
http://hdl.handle.net/11336/8044
dc.description.abstract
The modulatory effects of solar ultraviolet radiation (UVR) on the immune system have been widely studied. As the skin is the main target of UVR, our purpose was to compare the impact of two contrasting ways to be exposed to sunlight on the skin innate immunity. Hairless mice were UV irradiated with a single high UV dose (shUVd) simulating a harmful exposure, or with repetitive low UV doses (rlUVd) simulating short occasional daily exposures. Skin samples were taken at different times post-UV irradiation to evaluate skin histology, inflammatory cell recruitment, epidermal T cell population and the mitochondrial function of epidermal cells. The transcriptional profiles of pro-inflammatory cytokines, chemokines, antimicrobial peptides and TLRs were evaluated by RT-PCR and ELISA in tissue homogenates. Finally, a lymphangiography was performed to assess modification in the lymphatic vessel system. A shUVd produces a deep inflammatory state characterized by the production of pro-inflammatory cytokines and chemokines that, in turn, induces the recruitment of neutrophils and macrophages into the irradiated area. On the other hand, rlUVd drive the skin to a photo-induced alert state in which there is no sign of inflammation, but the epithelium undergoes changes in thickness, the lymphatic circulation increases, and the transcription of antimicrobial peptides is induced.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Inflammation
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Skin
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Ultraviolet Radiation
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Photoadaptation
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Chemotaxis
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Time-course study of different innate immune mediators produced by ultraviolet irradiated skin. Comparative effects between short and daily versus harmful and imprudent UV- exposures
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-07T15:41:42Z
dc.journal.volume
1
dc.journal.number
145
dc.journal.pagination
82-93
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Cela, Eliana Maiten. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
dc.description.fil
Fil: Friedrich, Adrián. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
dc.description.fil
Fil: Paz, Mariela Laura. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
dc.description.fil
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Leoni, Juliana. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
dc.description.fil
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
dc.journal.title
Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/imm.12427/abstract;jsessionid=802221F2556ED4E44B7753A243360490.f02t02
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/imm.12427
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405326/
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