Artículo
Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
Fecha de publicación:
06/2014
Editorial:
American Chemical Society
Revista:
ACS Nano
ISSN:
1936-0851
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine<br />adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical<br />model system to study biomembrane penetration by gold nanoparticles. The hydrogen redoxchemistry characteristic of ligand-stabilized gold nanoparticles in molecularly close contact with a mercury electrode is used as an indicator of membrane penetration. Results for water-dispersible gold nanoparticles of two different sizes are reported, and comparisons are made with the cellular uptake of the same preparations of nanoparticles by a common human fibroblast cell line. The experimental system described here can be used to study physicochemical aspects of membrane penetration in the absence of complex biological mechanisms, and it could also be a starting point for the development of a test bed for the toxicity of nanomaterials.
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Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Citación
Gordillo, Gabriel Jorge; Krpetic, Zeljka; Brust, Mathias; Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury; American Chemical Society; ACS Nano; 8; 6; 6-2014; 6074-6080
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