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Artículo

Estrogen inhibits tuberoinfundibular dopaminergic neurons but does not cause irreversible damage

Morel, Gustavo RamónIcon ; Caron, Ruben WalterIcon ; Console de Avegliano, Gloria Miriam; Soaje, MartaIcon ; Sosa, Yolanda ElenaIcon ; Rodríguez, Silvia SusanaIcon ; Jahn, Graciela AlmaIcon ; Goya, Rodolfo GustavoIcon
Fecha de publicación: 12/2009
Editorial: Pergamon-Elsevier Science Ltd
Revista: Brain Research Bulletin
ISSN: 0361-9230
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Dopaminergic neurons of the hypothalamic tuberoinfundibular dopaminergic (TIDA) system exert a tonic inhibitory control on prolactin (PRL) secretion whereas estrogen, known to inhibit TIDA neuron function, has been postulated to be toxic to TIDA neurons when it is chronically high. In order to determine whether estrogen in high doses can cause permanent damage to TIDA function, we submitted young female rats to continue high doses of estrogen administered, either centrally (intrahypothalamic estrogen implants) or peripherally (subcutaneous estrogen implants or weekly intramuscular (i.m.) injections for 7 weeks), subsequently withdrawing the steroid and observing the evolution of lactotrophes, serum PRL and TIDA neurons. Serum PRL was measured by radioimmunoassay whereas tyrosine hydroxylase positive (TH+) neurons and PRL cells were morphometrically assessed in sections of fixed hypothalami and pituitaries, respectively. After 30 days, hypothalamic estrogen implants induced a significant increase in serum PRL, whereas TH+ neurons were not detectable in the arcuate-periventricular hypothalamic (ARC) region of estrogen-implanted rats. Removal of implants on day 30 restored TH expression in the ARC and brought serum PRL back to basal levels 30 days after estrogen withdrawal. Subcutaneous or i.m. administration of estrogen for 7 weeks induced a marked hyperprolactinemia. However, 30 weeks after estrogen withdrawal, TH neuron numbers in the ARC were back to normal and serum PRL returned to basal levels. After peripheral but not central estrogen withdrawal, pituitary weight and lactotrophic cell numbers remained slightly increased. Our data suggest that estrogen even at high doses, does not cause permanent damage to TIDA neurons.
Palabras clave: 17-Β Estradiol , Aging , Hypothalamus , Prolactin , Reversible Inhibition , Tida Neurons
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/80340
DOI: http://dx.doi.org/10.1016/j.brainresbull.2009.08.026
URL: https://www.sciencedirect.com/science/article/pii/S0361923009002731
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829445/
Colecciones
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos(INIBIOLP)
Articulos de INST.DE INVEST.BIOQUIMICAS DE LA PLATA
Citación
Morel, Gustavo Ramón; Caron, Ruben Walter; Console de Avegliano, Gloria Miriam; Soaje, Marta; Sosa, Yolanda Elena; et al.; Estrogen inhibits tuberoinfundibular dopaminergic neurons but does not cause irreversible damage; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 80; 6; 12-2009; 347-352
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