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dc.contributor.author
Monserrat, José María
dc.contributor.author
Garcia, M. L.
dc.contributor.author
Ventura Lima, J.
dc.contributor.author
Gonzalez, Mariana
dc.contributor.author
Ballesteros, Maria Laura
dc.contributor.author
Miglioranza, Karina Silvia Beatriz
dc.contributor.author
Amé, María Valeria
dc.contributor.author
Wunderlin, Daniel Alberto
dc.date.available
2016-11-04T22:11:54Z
dc.date.issued
2013-11-01
dc.identifier.citation
Monserrat, José María; Garcia, M. L.; Ventura Lima, J.; Gonzalez, Mariana; Ballesteros, Maria Laura; et al.; Antioxidant, phase II and III responses induced by lipoic acid in the fish Jenynsia multidentata (Anablapidae) and its influence on endolsulfan accumulation and toxicity; Elsevier; Pesticide Biochemistry And Physiology; 108; 1-11-2013; 8-15
dc.identifier.issn
0048-3575
dc.identifier.uri
http://hdl.handle.net/11336/8010
dc.description.abstract
Antioxidants like lipoic acid (LA) are known to trigger augmented antioxidant and phase II and III responses. This study aimed to evaluate the effect of LA in P-glycoprotein (Pgp) expression, glutathione-S-transferase (GST) activity, total antioxidant competence, levels of lipid peroxides (TBARS) and accumulation of the organochlorine insecticide endosulfan (Endo: α-, β-isomers and sulfate metabolite) in different organs of the fish <em>Jenynsia multidentata</em>. One hundred and twenty females (1.55 ± 0.07 g) were fed during 8 days with (<em>n</em> = 60) or without (<em>n</em> = 60) a LA enriched ration (6000 mg/kg). Four experimental groups were defined: −LA/−Endo; +LA/−Endo; −LA/+Endo; and +LA/+Endo. Endo groups were exposed during 24 h to 1.4 μg of insecticide/L. Results showed that only LA induced a significant increment in liver Pgp expression. GST activity was augmented in liver after exposure to LA or Endo. TBARS levels were lowered in liver and gills after LA pre-treatment. Total antioxidant capacity was lowered in liver of Endo exposed fish, a result that was reversed by LA pre-treatment. It is concluded that LA induced the expected effects in terms of Pgp expression, GST activity and reduced TBARS levels although favored α-Endo accumulation in brain. However, the Endo metabolism to the more persistent endosulfan sulfate was not facilitated by LA pre-treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Lipoic Acid
dc.subject
Endosulfan
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Pgp Expression
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Antioxidant Defenses
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Oceanografía, Hidrología, Recursos Hídricos
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
dc.title
Antioxidant, phase II and III responses induced by lipoic acid in the fish Jenynsia multidentata (Anablapidae) and its influence on endolsulfan accumulation and toxicity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-02T18:13:37Z
dc.journal.volume
108
dc.journal.pagination
8-15
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Monserrat, José María. Universidade Federal do Rio Grande do Norte; Brasil. Instituto de Ciências Biológicas; Brasil
dc.description.fil
Fil: Garcia, M. L.. Universidade Federal do Rio Grande do Norte; Brasil. Instituto de Ciências Biológicas; Brasil
dc.description.fil
Fil: Ventura Lima, J.. Universidade Federal do Rio Grande do Norte; Brasil. Instituto de Ciências Biológicas; Brasil
dc.description.fil
Fil: Gonzalez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras; Argentina
dc.description.fil
Fil: Ballesteros, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras; Argentina
dc.description.fil
Fil: Miglioranza, Karina Silvia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras; Argentina
dc.description.fil
Fil: Amé, María Valeria. Universidad Nacional de Córdoba; Argentina
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Fil: Wunderlin, Daniel Alberto. Universidad Nacional de Córdoba; Argentina
dc.journal.title
Pesticide Biochemistry And Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.pestbp.2013.10.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0048357513001727


Archivos asociados

 

Comunidades y colecciones

  • Articulos(IDEA) [254]
    Articulos de INSTITUTO DE DIVERSIDAD Y ECOLOGIA ANIMAL
  • Articulos(ICYTAC) [144]
    Articulos de INST. DE CIENCIA Y TECNOLOGIA DE ALIMENTOS CORDOBA

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