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dc.contributor.author
Panero, Julieta
dc.contributor.author
Dos Santos, Patricia Carolina
dc.contributor.author
Slavutsky, Irma Rosa
dc.date.available
2019-07-23T16:17:39Z
dc.date.issued
2017-01
dc.identifier.citation
Panero, Julieta; Dos Santos, Patricia Carolina; Slavutsky, Irma Rosa; Telomere protein complexes and their role in lymphoid malignancies; Frontiers in bioscience; Frontiers in bioscience (Scholar edition); 9; 1-2017; 17-30
dc.identifier.issn
1945-0516
dc.identifier.uri
http://hdl.handle.net/11336/80058
dc.description.abstract
Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA. Due to the end replication problem, telomeres of somatic cells shorten with each cell division, inducing cell senescence. Telomerase is a reverse transcriptase capable of compensating telomere attrition by adding telomere repeats to the ends of chromosomes. Human telomeres are associated with the shelterin complex which consists of six telomere-associated proteins that specifically bind to telomeric DNA. Alterations or removal of individual shelterin components would lead to telomere uncapping and telomere dysfunction, resulting in cellular senescence and transformation to a malignant state. Another complex of multifunctional proteins, named non-shelterin complex, is thought to prevent telomere degradation and facilitate telomerase-based telomere elongation. As telomerase is highly expressed in most human tumor cells, it is considered an attractive target for new therapeutic strategies. In this review, we will summarize the characteristics of telomeres and telomerase in lymphoid malignancies and discuss the role of telomere-associated proteins in these entities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in bioscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lymphoid Malignancies
dc.subject
Gene Expression
dc.subject
Telomerase
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Genética Humana
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Telomere protein complexes and their role in lymphoid malignancies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-13T18:31:37Z
dc.journal.number
9
dc.journal.pagination
17-30
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Panero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Dos Santos, Patricia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; Argentina. Laboratorio de Genética de Neoplasias Linfoides; Argentina
dc.description.fil
Fil: Slavutsky, Irma Rosa. Laboratorio de Genética de Neoplasias Linfoides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; Argentina
dc.journal.title
Frontiers in bioscience (Scholar edition)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/27814571
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.bioscience.org/2017/v9s/af/469/fulltext.htm
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