Artículo
Activation of central melanocortin pathways by fenfluramine
Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; Smart, James L.; Rubinstein, Marcelo
; Tatro, Jeffrey B.; Marcus, Jacob N.; Holstege, Henne; Lee, Charlotte E.; Cone, Roger D.; Elmquist, Joel K.
Fecha de publicación:
07/2002
Editorial:
American Association for the Advancement of Science
Revista:
Science
ISSN:
0036-8075
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments.
Palabras clave:
Serotonina
,
Melanocortinas
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; et al.; Activation of central melanocortin pathways by fenfluramine; American Association for the Advancement of Science; Science; 297; 5581; 7-2002; 609-611
Compartir
Altmétricas