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dc.contributor.author
Dagdas, Yasin F.
dc.contributor.author
Pandey, Pooja
dc.contributor.author
Tumtas, Yasin
dc.contributor.author
Sanguankiattichai, Nattapong
dc.contributor.author
Belhaj, Khaoula
dc.contributor.author
Duggan, Cian
dc.contributor.author
Leary, Alexandre Y.
dc.contributor.author
Segretin, Maria Eugenia
dc.contributor.author
Contreras, Mauricio P.
dc.contributor.author
Savage, Zachary
dc.contributor.author
Khandare, Virendrasinh S.
dc.contributor.author
Kamoun, Sophien
dc.contributor.author
Bozkurt, Osman Tolga
dc.date.available
2019-07-19T15:42:09Z
dc.date.issued
2018-06
dc.identifier.citation
Dagdas, Yasin F.; Pandey, Pooja; Tumtas, Yasin; Sanguankiattichai, Nattapong; Belhaj, Khaoula; et al.; Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the irish potato famine pathogen; eLife Sciences Publications Ltd; eLife; 7; 6-2018; 1-15
dc.identifier.issn
2050-084X
dc.identifier.uri
http://hdl.handle.net/11336/79890
dc.description.abstract
During plant cell invasion, the oomycete Phytophthora infestans remains enveloped by host-derived membranes whose functional properties are poorly understood. P. infestans secretes a myriad of effector proteins through these interfaces for plant colonization. Recently we showed that the effector protein PexRD54 reprograms host-selective autophagy by antagonising antimicrobial-autophagy receptor Joka2/NBR1 for ATG8CL binding (Dagdas et al., 2016). Here, we show that during infection, ATG8CL/Joka2 labelled defense-related autophagosomes are diverted toward the perimicrobial host membrane to restrict pathogen growth. PexRD54 also localizes to autophagosomes across the perimicrobial membrane, consistent with the view that the pathogen remodels host-microbe interface by co-opting the host autophagy machinery. Furthermore, we show that the host-pathogen interface is a hotspot for autophagosome biogenesis. Notably, overexpression of the early autophagosome biogenesis protein ATG9 enhances plant immunity. Our results implicate selective autophagy in polarized immune responses of plants and point to more complex functions for autophagy than the widely known degradative roles.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Autophagy
dc.subject
Immunity
dc.subject
Phytophthora Infestans
dc.subject
Effector
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the irish potato famine pathogen
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-17T13:13:31Z
dc.journal.volume
7
dc.journal.pagination
1-15
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Dagdas, Yasin F.. Norwich Research Park; Reino Unido. Vienna Biocenter; Austria
dc.description.fil
Fil: Pandey, Pooja. Imperial College London; Reino Unido
dc.description.fil
Fil: Tumtas, Yasin. Imperial College London; Reino Unido
dc.description.fil
Fil: Sanguankiattichai, Nattapong. Imperial College London; Reino Unido
dc.description.fil
Fil: Belhaj, Khaoula. Norwich Research Park; Reino Unido
dc.description.fil
Fil: Duggan, Cian. Imperial College London; Reino Unido
dc.description.fil
Fil: Leary, Alexandre Y.. Imperial College London; Reino Unido
dc.description.fil
Fil: Segretin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Contreras, Mauricio P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Imperial College London; Reino Unido
dc.description.fil
Fil: Savage, Zachary. Imperial College London; Reino Unido
dc.description.fil
Fil: Khandare, Virendrasinh S.. Imperial College London; Reino Unido
dc.description.fil
Fil: Kamoun, Sophien. Norwich Research Park; Reino Unido
dc.description.fil
Fil: Bozkurt, Osman Tolga. Imperial College London; Reino Unido
dc.journal.title
eLife
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.37476
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/37476


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  • Articulos(INGEBI) [514]
    Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"

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