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dc.contributor.author
Ellison, Michael  
dc.contributor.author
Haberlandt, Christian  
dc.contributor.author
Gomez Casati, Maria Eugenia  
dc.contributor.author
Watkins, Maren  
dc.contributor.author
Elgoyhen, Ana Belen  
dc.contributor.author
McIntosh, J. Michael  
dc.contributor.author
Olivera, Baldomero M.  
dc.date.available
2019-07-18T21:40:55Z  
dc.date.issued
2006-02  
dc.identifier.citation
Ellison, Michael; Haberlandt, Christian; Gomez Casati, Maria Eugenia; Watkins, Maren; Elgoyhen, Ana Belen; et al.; α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR; American Chemical Society; Biochemistry; 45; 5; 2-2006; 1511-1517  
dc.identifier.issn
0006-2960  
dc.identifier.uri
http://hdl.handle.net/11336/79876  
dc.description.abstract
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea. In addition α9 and/or α10 expression has been described in dorsal root ganglion neurons, lymphocytes, skin keratinocytes, and the pars tuberalis of the pituitary. Specific antagonists that selectively block the α9α10 channel could be valuable tools for elucidating its role in these diverse tissues. This study describes a novel α-conotoxin from the Western Atlantic species Conus regius, α-conotoxin RgIA (α-RgIA), that is a subtype specific blocker of the α9α10 nAChR. α-RgIA belongs to the α4/3 subfamily of the α-conotoxin family; sequence and subtype specificity comparisons between α-RgIA and previously characterized α4/3 toxins indicate that the amino acids in the C-terminal half of α-RgIA are responsible for its preferential inhibition of the α9α10 nAChR subtype  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Chemical Society  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Nicotinic Acetylcholine Receptors  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-07-18T13:02:39Z  
dc.journal.volume
45  
dc.journal.number
5  
dc.journal.pagination
1511-1517  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Washington  
dc.description.fil
Fil: Ellison, Michael. University of Utah; Estados Unidos  
dc.description.fil
Fil: Haberlandt, Christian. University of Utah; Estados Unidos  
dc.description.fil
Fil: Gomez Casati, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina  
dc.description.fil
Fil: Watkins, Maren. University of Utah; Estados Unidos  
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina  
dc.description.fil
Fil: McIntosh, J. Michael. University of Utah; Estados Unidos  
dc.description.fil
Fil: Olivera, Baldomero M.. University of Utah; Estados Unidos  
dc.journal.title
Biochemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/bi0520129  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1021/bi0520129