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Artículo

Compartmentalization of antagonistic Ca2+ signals in developing cochlear hair cells

Moglie, Marcelo JavierIcon ; Fuchs, Paul A.; Elgoyhen, Ana BelenIcon ; Goutman, Juan DiegoIcon
Fecha de publicación: 02/2018
Editorial: National Academy of Sciences
Revista: Proceedings of the National Academy of Sciences of The United States of America
ISSN: 0027-8424
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biofísica

Resumen

During a critical developmental period, cochlear inner hair cells (IHCs) exhibit sensory-independent activity, featuring action potentials in which Ca2+ ions play a fundamental role in driving both spiking and glutamate release onto synapses with afferent auditory neurons. This spontaneous activity is controlled by a cholinergic input to the IHC, activating a specialized nicotinic receptor with high Ca2+ permeability, and coupled to the activation of hyperpolarizing SK channels. The mechanisms underlying distinct excitatory and inhibitory Ca2+ roles within a small, compact IHC are unknown. Making use of Ca2+ imaging, afferent auditory bouton recordings, and electron microscopy, the present work shows that unusually high intracellular Ca2+ buffering and "subsynaptic" cisterns provide efficient compartmentalization and tight control of cholinergic Ca2+ signals. Thus, synaptic efferent Ca2+ spillover and cross-talk are prevented, and the cholinergic input preserves its inhibitory signature to ensure normal development of the auditory system.
Palabras clave: Calcium , Cochlea , Hair Cells , Synaptic Transmission
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/79840
DOI: http://dx.doi.org/10.1073/pnas.1719077115
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29439202/
URL: https://www.pnas.org/content/115/9/E2095
Colecciones
Articulos(INGEBI)
Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"
Citación
Moglie, Marcelo Javier; Fuchs, Paul A.; Elgoyhen, Ana Belen; Goutman, Juan Diego; Compartmentalization of antagonistic Ca2+ signals in developing cochlear hair cells; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 115; 9; 2-2018; E2095-E2104
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