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dc.contributor.author
Heisler, Lora K.
dc.contributor.author
Cowley, Michael A.
dc.contributor.author
Kishi, Toshiro
dc.contributor.author
Tecott, Laurence H.
dc.contributor.author
Fan, Wei
dc.contributor.author
Low, Malcolm J.
dc.contributor.author
Smart, James L.
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Tatro, Jeffrey B.
dc.contributor.author
Zigman, Jeffrey M.
dc.contributor.author
Cone, Roger D.
dc.contributor.author
Elmquist, Joel K.
dc.date.available
2019-07-18T19:10:29Z
dc.date.issued
2003-06
dc.identifier.citation
Heisler, Lora K.; Cowley, Michael A.; Kishi, Toshiro; Tecott, Laurence H.; Fan, Wei; et al.; Central serotonin and melanocortin pathways regulating energy homeostasis; The New York Academy of Sciences; Annals of the New York Academy of Sciences; 994; 6-2003; 169-174
dc.identifier.issn
0077-8923
dc.identifier.uri
http://hdl.handle.net/11336/79832
dc.description.abstract
It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and neurotransmitters systems within the hypothalamus has yet to be delineated. Recently, we investigated the mechanisms through which central serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we found that 5-HT drugs require functional melanocortin pathways to exert their effects on food intake. Specifically, we observed that anorectic 5-HT drugs activate pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (Arc). We provide evidence that the serotonin 2C receptor (5-HT2CR) is expressed on POMC neurons and contributes to this effect. Finally, we found that 5-HT drug-induced hypophagia is attenuated by pharmacological or genetic blockade of downstream melanocortin 3 and 4 receptors. We review candidate brain regions expressing melanocortin 3 and 4 receptors that play a role in energy balance. A model is presented in which activation of the melanocortin system is downstream of 5-HT and is necessary to produce the complete anorectic effect of 5-HT drugs. The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
The New York Academy of Sciences
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
And Arcuate Nucleus
dc.subject
Body Weight
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Food Intake
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Hypothalamus
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Melanocortin
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Melanocortin 4 Receptor (Mc4-R)
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Pro-Opiomelanocortin (Pomc)
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Serotonin
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Serotonin 2c Receptor (5-Ht2cr)
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Central serotonin and melanocortin pathways regulating energy homeostasis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-16T14:12:53Z
dc.journal.volume
994
dc.journal.pagination
169-174
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Heisler, Lora K.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Cowley, Michael A.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Kishi, Toshiro. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Tecott, Laurence H.. University of California; Estados Unidos
dc.description.fil
Fil: Fan, Wei. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Smart, James L.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados Unidos
dc.description.fil
Fil: Zigman, Jeffrey M.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Cone, Roger D.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Elmquist, Joel K.. Harvard Medical School; Estados Unidos
dc.journal.title
Annals of the New York Academy of Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/12851313
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1749-6632.2003.tb03177.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03177.x


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