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dc.contributor.author
Langguth, Berthold
dc.contributor.author
Elgoyhen, Ana Belen
dc.contributor.author
Cederroth, Christopher R.
dc.date.available
2019-07-18T19:07:31Z
dc.date.issued
2019-01
dc.identifier.citation
Langguth, Berthold; Elgoyhen, Ana Belen; Cederroth, Christopher R.; Therapeutic approaches to the treatment of tinnitus; Annual Reviews; Annual Review Of Pharmacology And Toxicology; 59; 1-2019; 291-313
dc.identifier.issn
0362-1642
dc.identifier.uri
http://hdl.handle.net/11336/79829
dc.description.abstract
Tinnitus is a highly prevalent condition that is associated with hearing loss in most cases. In the absence of external stimuli, phantom perceptions of sounds emerge from alterations in neuronal activity within central auditory and nonauditory structures. Pioneering studies using lidocaine revealed that tinnitus is susceptible to pharmacological interventions. However, lidocaine is not effective in all patients, and no other drug has been identified with clear efficacy for the long-term treatment of tinnitus. In this review, we present recent advances in tinnitus research, including more detailed knowledge of its pathophysiology and involved neurotransmitter systems. Moreover, we summarize results from animal and clinical treatment studies as well as from studies that identified tinnitus as a side effect of pharmacological treatments. Finally, we focus on challenges in the development of pharmacological compounds for the treatment of tinnitus, namely the limitations of available animal models and of standardized clinical research methodologies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Annual Reviews
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hearing Loss
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Neural Networks
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Phantom Sound
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Plasticity
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Tinnitus
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Therapeutic approaches to the treatment of tinnitus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-17T13:14:39Z
dc.journal.volume
59
dc.journal.pagination
291-313
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Palo Alto
dc.description.fil
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Cederroth, Christopher R.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.journal.title
Annual Review Of Pharmacology And Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-010818-021556
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1146/annurev-pharmtox-010818-021556
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/30044727
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