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Artículo

A novel electrophysiologic effect of melatonin on ischemia/reperfusion- induced arrhythmias in isolated rat hearts

Diez, Emiliano RaúlIcon ; Prados, Laura Vanina; Carrión, Adriana; Ponce Zumino, Amira ZulmaIcon ; Miatello, Roberto MiguelIcon
Fecha de publicación: 03/2009
Editorial: Wiley Blackwell Publishing, Inc
Revista: Journal of Pineal Research
ISSN: 0742-3098
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Reperfusion after a short period of cardiac ischemia triggers ventricular arrhythmias attributable to ionic imbalance and oxidative stress. Melatonin offers some degree of protection, but its effects on the cardiac action potentials are unknown. We evaluated the effects of 5, 10, 20 and 50 μm melatonin in isolated perfused rat hearts subjected to 10 min of regional ischemia. ECG and membrane potentials were synchronously displayed. After 15 min of reperfusion, total antioxidant capacity (TAC) was determined. Melatonin did not change the ischemic depolarization nor the action potential amplitude depression, but at the end of ischemia the action potential duration (APD) decreased in control and 5 μm melatonin-treated hearts. By contrast, it returned to preischemic levels in hearts given 20 and 50 μm melatonin. Melatonin reduced the incidence of reperfusion arrhythmias from 100% in control to 50% in 5 and 10 μm, to 40% in 20 μm and 30% in 50 μm hearts. TAC values were higher at all melatonin concentrations. We conclude that melatonin reduced the incidence of reperfusion arrhythmias because of its antioxidant effects. In addition, at 20 and 50 μm lengthened APD and promoted an improved protection. This latter effect should be considered when in vivo applications of melatonin are considered.
Palabras clave: Antioxidant , Arrhythmias , Electrophysiology , Ischemia-Reperfusion Injury , Melatonin , Rat , Transmembrane Action Potential
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/79665
DOI: http://dx.doi.org/10.1111/j.1600-079X.2008.00643.x
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.2008.00643.x
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Articulos(IMBECU) [385]
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Diez, Emiliano Raúl; Prados, Laura Vanina; Carrión, Adriana; Ponce Zumino, Amira Zulma; Miatello, Roberto Miguel; A novel electrophysiologic effect of melatonin on ischemia/reperfusion- induced arrhythmias in isolated rat hearts; Wiley Blackwell Publishing, Inc; Journal of Pineal Research; 46; 2; 3-2009; 155-160
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