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dc.contributor.author
Ruete, María Celeste
dc.contributor.author
Carrizo, Liliana C.
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Bocanegra, María Victoria
dc.contributor.author
Vallés, Patricia G.
dc.date.available
2019-07-16T18:53:59Z
dc.date.issued
2009-03
dc.identifier.citation
Ruete, María Celeste; Carrizo, Liliana C.; Bocanegra, María Victoria; Vallés, Patricia G.; Altered renal expression of Na + transporters and ROMK in protein-deprived rats; Karger; Nephron Physiology; 111; 3; 3-2009; 17-29
dc.identifier.issn
1660-2137
dc.identifier.uri
http://hdl.handle.net/11336/79660
dc.description.abstract
Potassium depletion has been associated with altered sodium reabsorption in tubule segments. We studied if the altered abundance of Na+ transporters and ROMK are associated with distal potassium secretion that contributes to the development of hypokalemia in protein-deprived rats. After weaning, Wistar rats were fed with a low-protein diet (8%, LP) for 14 days and then recovered with a normal-protein (NP) diet (24%, RP). An age-matched control group was fed with an NP diet (24%, NP). We showed hypokalemia, lower glomerular filtration rate and higher FEK+ in the LP group. Immunoblotting revealed that the type 3 Na+/H+ exchanger in the cortex was decreased in the LP group. However, the type 2 Na +-K+-2Cl- cotransporter was increased in the outer stripe of the outer medulla in the LP group. The abundance of the aldosterone-regulated Na+-Cl- cotransporter (NCC) and epithelial Na+ channel (ENaC) was higher in the LP group and was associated with higher plasma aldosterone level. ROMK protein levels were increased. Na+/K+-ATPase protein levels were the same in both groups. After the recovery period, the expression of Na+ transporters and ROMK returned to control values. We conclude that increased expression of NCC, ENaC subunits, and ROMK contributed to distal potassium secretion leading to enhanced potassium excretion, which may explain the hypokalemia resulting from LP feeding. A role of aldosterone may be suggested.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hypokalemia
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Low-Protein Diet
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Sodium Transporters
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Altered renal expression of Na + transporters and ROMK in protein-deprived rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T21:52:08Z
dc.journal.volume
111
dc.journal.number
3
dc.journal.pagination
17-29
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Ruete, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Carrizo, Liliana C.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Bocanegra, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Vallés, Patricia G.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Nephron Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1159/000199462
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/199462