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dc.contributor.author
Franchini, Lucia Florencia
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dc.contributor.author
Elgoyhen, Ana Belen
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dc.date.available
2019-07-16T18:20:46Z
dc.date.issued
2006-12
dc.identifier.citation
Franchini, Lucia Florencia; Elgoyhen, Ana Belen; Adaptive evolution in mammalian proteins involved in cochlear outer hair cell electromotility; Academic Press Inc Elsevier Science; Molecular Phylogenetics and Evolution; 41; 3; 12-2006; 622-635
dc.identifier.issn
1055-7903
dc.identifier.uri
http://hdl.handle.net/11336/79650
dc.description.abstract
Somatic electromotility in cochlear outer hair cells, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon rapid cell length changes proposed to be mediated by the motor-protein prestin, a member of the solute carrier anion-transport family 26. Thus, one might predict that prestin has specifically evolved in mammals to support this unique mammalian adaptation. Using codon-based likelihood models we found evidences for positive selection in the motor-protein prestin only in the mammalian lineage, supporting the hypothesis that lineage-specific adaptation-driven molecular changes endowed prestin with the ability to mediate somatic electromotility. Moreover, signatures of positive selection were found on the α10, but not the α9, nicotinic cholinergic receptor subunits. An α9α10-containing nicotinic cholinergic receptor mediates inhibitory olivocochlear efferent effects on hair cells across vertebrates. Our results suggest that evolution-driven modifications of the α10 subunit probably allowed the α9α10 heteromeric receptor to serve a differential function in the mammalian cochlea. Thus, we describe for the first time at the molecular level signatures of adaptive evolution in two outer hair cell proteins only in the lineage leading to mammals. This finding is most likely related with the roles these proteins play in somatic electromotility and/or its fine tuning.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acetylcholine
dc.subject
Adaptive Evolution
dc.subject
Hearing
dc.subject
Nicotinic Receptors
dc.subject
Outer Hair Cells
dc.subject
Prestin
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Adaptive evolution in mammalian proteins involved in cochlear outer hair cell electromotility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-15T13:54:57Z
dc.journal.volume
41
dc.journal.number
3
dc.journal.pagination
622-635
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires; Argentina
dc.journal.title
Molecular Phylogenetics and Evolution
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ympev.2006.05.042
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1055790306002016
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