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dc.contributor.author
Kelly, M. A.
dc.contributor.author
Low, M. J.
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Phillips, T. J.
dc.date.available
2019-07-16T17:44:36Z
dc.date.issued
2008-07
dc.identifier.citation
Kelly, M. A.; Low, M. J.; Rubinstein, Marcelo; Phillips, T. J.; Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 7; 5; 7-2008; 568-577
dc.identifier.issn
1601-1848
dc.identifier.uri
http://hdl.handle.net/11336/79641
dc.description.abstract
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dopamine Receptors
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Knockout
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Locomotor Activity
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Neuroadaptation
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Null Mutant
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Psychostimulant
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Sensitization
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-15T13:54:31Z
dc.journal.volume
7
dc.journal.number
5
dc.journal.pagination
568-577
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Kelly, M. A.. Oregon Health And Science University; Estados Unidos
dc.description.fil
Fil: Low, M. J.. Oregon Health And Science University; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
dc.description.fil
Fil: Phillips, T. J.. Oregon Health And Science University; Estados Unidos
dc.journal.title
Genes, Brain and Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18363855/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1601-183X.2008.00392.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2008.00392.x
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