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dc.contributor.author
Moratorio, Gonzalo
dc.contributor.author
Martínez, Mariela
dc.contributor.author
Gutiérrez, María F.
dc.contributor.author
González, Katiuska
dc.contributor.author
Colina, Rodney
dc.contributor.author
López Tort, Fernando
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López, Lilia
dc.contributor.author
Recarey, Ricardo
dc.contributor.author
Schijman, Alejandro Gabriel
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dc.contributor.author
Moreno, María P.
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García Aguirre, Laura
dc.contributor.author
Manascero, Aura R.
dc.contributor.author
Cristina, Juan
dc.date.available
2019-07-16T17:29:15Z
dc.date.issued
2007-12
dc.identifier.citation
Moratorio, Gonzalo; Martínez, Mariela; Gutiérrez, María F.; González, Katiuska; Colina, Rodney; et al.; Evolution of naturally occurring 5'non-coding region variants of Hepatitis C virus in human populations of the South American region; BioMed Central; Virology Journal; 4; 79; 12-2007; 1-12
dc.identifier.issn
1743-422X
dc.identifier.uri
http://hdl.handle.net/11336/79636
dc.description.abstract
Background. Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease has emerged. Previous and recent studies have suggested a diversification of type 1 HCV in the South American region. The degree of genetic variation among HCV strains circulating in Bolivia and Colombia is currently unknown. In order to get insight into these matters, we performed a phylogenetic analysis of HCV 5' non-coding region (5'NCR) sequences from strains isolated in Bolivia, Colombia and Uruguay, as well as available comparable sequences of HCV strains isolated in South America. Methods. Phylogenetic tree analysis was performed using the neighbor-joining method under a matrix of genetic distances established under the Kimura-two parameter model. Signature pattern analysis, which identifies particular sites in nucleic acid alignments of variable sequences that are distinctly representative relative to a background set, was performed using the method of Korber & Myers, as implemented in the VESPA program. Prediction of RNA secondary structures was done by the method of Zuker & Turner, as implemented in the mfold program. Results. Phylogenetic tree analysis of HCV strains isolated in the South American region revealed the presence of a distinct genetic lineage inside genotype 1. Signature pattern analysis revealed that the presence of this lineage is consistent with the presence of a sequence signature in the 5'NCR of HCV strains isolated in South America. Comparisons of these results with the ones found for Europe or North America revealed that this sequence signature is characteristic of the South American region. Conclusion. Phylogentic analysis revealed the presence of a sequence signature in the 5'NCR of type 1 HCV strains isolated in South America. This signature is frequent enough in type 1 HCV populations circulating South America to be detected in a phylogenetic tree analysis as a distinct type 1 sub-population. The coexistence of distinct type 1 HCV subpopulations is consistent with quasispecies dynamics, and suggests that multiple coexisting subpopulations may allow the virus to adapt to its human host populations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Genotyping
dc.subject
Hepatitis C Virus
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5' Non Coding Region
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Evolution of naturally occurring 5'non-coding region variants of Hepatitis C virus in human populations of the South American region
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-15T13:53:53Z
dc.journal.volume
4
dc.journal.number
79
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Moratorio, Gonzalo. Universidad de la República; Uruguay
dc.description.fil
Fil: Martínez, Mariela. Universidad de la República; Uruguay
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Fil: Gutiérrez, María F.. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: González, Katiuska. Universidad Mayor de San Andrés; Bolivia
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Fil: Colina, Rodney. McGill University; Canadá
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Fil: López Tort, Fernando. Universidad de la República; Uruguay
dc.description.fil
Fil: López, Lilia. Universidad de la República; Uruguay
dc.description.fil
Fil: Recarey, Ricardo. Universidad de la República; Uruguay
dc.description.fil
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Moreno, María P.. Universidad de la República; Uruguay
dc.description.fil
Fil: García Aguirre, Laura. Universidad de la República; Uruguay
dc.description.fil
Fil: Manascero, Aura R.. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Cristina, Juan. Universidad de la República; Uruguay
dc.journal.title
Virology Journal
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-4-79
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1743-422X-4-79
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