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dc.contributor.author
McIntosh, J. Michael
dc.contributor.author
Absalom, Nathan
dc.contributor.author
Chebib, Mary
dc.contributor.author
Elgoyhen, Ana Belen
dc.contributor.author
Vincler, Michelle
dc.date.available
2019-07-16T15:12:46Z
dc.date.issued
2009-10
dc.identifier.citation
McIntosh, J. Michael; Absalom, Nathan; Chebib, Mary; Elgoyhen, Ana Belen; Vincler, Michelle; Alpha9 nicotinic acetylcholine receptors and the treatment of pain; Pergamon-Elsevier Science Ltd; Biochemical Pharmacology; 78; 7; 10-2009; 693-702
dc.identifier.issn
0006-2952
dc.identifier.uri
http://hdl.handle.net/11336/79623
dc.description.abstract
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms. Even when these medications are used in combination, substantial amounts of pain often remain. It is therefore highly desirable to develop treatments that work through distinct mechanisms of action. While agonists of nicotinic acetylcholine receptors (nAChRs) have been intensively studied, new data suggest a role for selective antagonists of nAChRs. α-Conotoxins are small peptides used offensively by carnivorous marine snails known as Conus. A subset of these peptides known as α-conotoxins RgIA and Vc1.1 produces both acute and long lasting analgesia. In addition, these peptides appear to accelerate the recovery of function after nerve injury, possibly through immune mediated mechanisms. Pharmacological analysis indicates that RgIA and Vc1.1 are selective antagonists of α9α10 nAChRs. A recent study also reported that these α9α10 antagonists are also potent GABA-B agonists. In the current study, we were unable to detect RgIA or Vc1.1 binding to or action on cloned GABA-B receptors expressed in HEK cells or Xenopus oocytes. We review the background, findings and implications of use of compounds that act on α9* nAChRs.11* indicates the possible presence of additional subunits.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Α-Conotoxin Vc1.1
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Α-Contoxin Rgia
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Alpha9 Nicotinic
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Gaba-B
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Pain
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Alpha9 nicotinic acetylcholine receptors and the treatment of pain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-11T19:22:05Z
dc.journal.volume
78
dc.journal.number
7
dc.journal.pagination
693-702
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: McIntosh, J. Michael. University of Utah; Estados Unidos
dc.description.fil
Fil: Absalom, Nathan. The University of Sydney; Australia
dc.description.fil
Fil: Chebib, Mary. The University of Sydney; Australia
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Vincler, Michelle. Wake Forest University Health Sciences; Estados Unidos
dc.journal.title
Biochemical Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19477168/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bcp.2009.05.020
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006295209004298
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