Artículo
Evaluation of angiogenesis with the expression of VEGF-C and CD34 in human colon cancer
Inda, Ana María; García, Marcela Nilda; Andrini, Laura Beatríz; García, Adriana Laura; Fernandez Blanco, Ayelen; Furnus, Cecilia Cristina
; Galletti, Susana Mercedes; Brandoni, Javier; Martinez, Jorge Guillermo; Prat, Guillermo Daniel; Errecalde, Ana Lia
Fecha de publicación:
09/2009
Editorial:
Bentham Science Publishers
Revista:
Current Chemical Biology
ISSN:
1872-3136
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: The most potent angiogenic factor is the vascular endothelial growth factor (VEGF), and CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a direct marker of the degree of neoangiogenesis. In the present study we report that VEGF expression and its relationship with MVD, in poorly and well differentiated colon adenocarcinoma, in order to consider the possibility of using the correlation between both antibodies as a prognostic factor. Materials and Methods: Tumor sections were stained by immunohistochemistry for CD34 and VEGF. Results: The mean of VEGF and CD34 did not show any significant differences between both types of tumors. Conclusion: The conventional factors taken into consideration were not significantly related to the angiogenic factors examined, so we could affirm that the correlation of both markers could be useful as prognostic factor.
Palabras clave:
Adenocarcinoma
,
Angiogenesis
,
Cd34
,
Colon
,
Colon Cancer
,
Vegf
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Colecciones
Articulos(IGEVET)
Articulos de INST.DE GENETICA VET ING FERNANDO NOEL DULOUT
Articulos de INST.DE GENETICA VET ING FERNANDO NOEL DULOUT
Citación
Inda, Ana María; García, Marcela Nilda; Andrini, Laura Beatríz; García, Adriana Laura; Fernandez Blanco, Ayelen; et al.; Evaluation of angiogenesis with the expression of VEGF-C and CD34 in human colon cancer; Bentham Science Publishers; Current Chemical Biology; 3; 3; 9-2009; 302-305
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