Mostrar el registro sencillo del ítem
dc.contributor.author
Thanos, P. K.
dc.contributor.author
Bermeo, C.
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Suchland, K. L.
dc.contributor.author
Wang, G. J.
dc.contributor.author
Grandy, David K.
dc.contributor.author
Volkow, N. D.
dc.date.available
2019-07-15T20:35:24Z
dc.date.issued
2010-06
dc.identifier.citation
Thanos, P. K.; Bermeo, C.; Rubinstein, Marcelo; Suchland, K. L.; Wang, G. J.; et al.; Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors; Sage Publications Ltd; Journal Of Psychopharmacology; 24; 6; 6-2010; 897-904
dc.identifier.issn
0269-8811
dc.identifier.uri
http://hdl.handle.net/11336/79582
dc.description.abstract
Methylphenidate (MP) and amphetamine (AMPH) are the most frequently prescribed medications for the treatment of attention-deficit/hyperactivity disorder (ADHD). Both drugs are believed to derive their therapeutic benefit by virtue of their dopamine (DA)-enhancing effects, yet an explanation for the observation that some patients with ADHD respond well to one medication but not to the other remains elusive. The dopaminergic effects of MP and AMPH are also thought to underlie their reinforcing properties and ultimately their abuse. Polymorphisms in the human gene that codes for the DA D4 receptor (D4R) have been repeatedly associated with ADHD and may correlate with the therapeutic as well as the reinforcing effects of responses to these psychostimulant medications. Conditioned place preference (CPP) for MP, AMPH and cocaine were evaluated in wild-type (WT) mice and their genetically engineered littermates, congenic on the C57Bl/6J background, that completely lack D4Rs (knockout or KO). In addition, the locomotor activity in these mice during the conditioning phase of CPP was tested in the CPP chambers. D4 receptor KO and WT mice showed CPP and increased locomotor activity in response to each of the three psychostimulants tested. D4R differentially modulates the CPP responses to MP, AMPH and cocaine. While the D4R genotype affected CPP responses to MP (high dose only) and AMPH (low dose only) it had no effects on cocaine. Inasmuch as CPP is considered an indicator of sensitivity to reinforcing responses to drugs these data suggest a significant but limited role of D4Rs in modulating conditioning responses to MP and AMPH. In the locomotor test, D4 receptor KO mice displayed attenuated increases in AMPH-induced locomotor activity whereas responses to cocaine and MP did not differ. These results suggest distinct mechanisms for D4 receptor modulation of the reinforcing (perhaps via attenuating dopaminergic signalling) and locomotor properties of these stimulant drugs. Thus, individuals with D4 receptor polymorphisms might show enhanced reinforcing responses to MP and AMPH and attenuated locomotor response to AMPH.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sage Publications Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Addiction
dc.subject
Environment
dc.subject
Learning
dc.subject
Novelty
dc.subject
Psychostimulants
dc.subject
Substance Abuse
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-10T19:05:11Z
dc.journal.volume
24
dc.journal.number
6
dc.journal.pagination
897-904
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Londres
dc.description.fil
Fil: Thanos, P. K.. NIAAA Intramural Program; Estados Unidos. Brookhaven National Laboratory; Estados Unidos. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Bermeo, C.. Brookhaven National Laboratory; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Suchland, K. L.. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: Wang, G. J.. Brookhaven National Laboratory; Estados Unidos
dc.description.fil
Fil: Grandy, David K.. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: Volkow, N. D.. NIAAA Intramural Program; Estados Unidos
dc.journal.title
Journal Of Psychopharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19282420/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0269881109102613
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/0269881109102613
Archivos asociados