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dc.contributor.author
Coelho, Claudia
dc.contributor.author
Figueiredo, Ricardo
dc.contributor.author
Frank, Elmar
dc.contributor.author
Burger, Julia
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Schecklmann, Martin
dc.contributor.author
Landgrebe, Michael
dc.contributor.author
Langguth, Berthold
dc.contributor.author
Elgoyhen, Ana Belen
dc.date.available
2019-07-11T19:54:25Z
dc.date.issued
2012-04
dc.identifier.citation
Coelho, Claudia; Figueiredo, Ricardo; Frank, Elmar; Burger, Julia; Schecklmann, Martin; et al.; Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study; Karger; Audiology And Neuro-otology; 17; 3; 4-2012; 179-188
dc.identifier.issn
1420-3030
dc.identifier.uri
http://hdl.handle.net/11336/79403
dc.description.abstract
Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Muscle Relaxants
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Phantom Perception
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Somatosensory System
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Tinnitus
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-10T13:41:01Z
dc.journal.volume
17
dc.journal.number
3
dc.journal.pagination
179-188
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Coelho, Claudia. University of Iowa; Estados Unidos. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Figueiredo, Ricardo. Clinical and Research Tinnitus Center; Brasil
dc.description.fil
Fil: Frank, Elmar. Universitat Regensburg; Alemania
dc.description.fil
Fil: Burger, Julia. Universitat Regensburg; Alemania
dc.description.fil
Fil: Schecklmann, Martin. Universitat Regensburg; Alemania
dc.description.fil
Fil: Landgrebe, Michael. Universitat Regensburg; Alemania
dc.description.fil
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.journal.title
Audiology And Neuro-otology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1159/000335657
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/335657
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