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dc.contributor.author
Aguirre, María Victoria
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dc.contributor.author
Todaro, Juan Santiago
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dc.contributor.author
Juaristi, Julian Antonio
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dc.contributor.author
Brandan, Nora Cristina
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dc.date.available
2019-07-11T15:40:25Z
dc.date.issued
2010-06
dc.identifier.citation
Aguirre, María Victoria; Todaro, Juan Santiago; Juaristi, Julian Antonio; Brandan, Nora Cristina; Murine erythropoietic impairment induced by paclitaxel: Interactions of GATA-1 and erythroid Krüppel-like transcription factors, apoptotic related proteins and erythropoietin receptor; Elsevier Science; European Journal of Pharmacology; 636; 1-3; 6-2010; 42-51
dc.identifier.issn
0014-2999
dc.identifier.uri
http://hdl.handle.net/11336/79347
dc.description.abstract
Paclitaxel, an antitumoral drug, was used in a single dose (29mg/kg i.p.) as an injury agent for inducing transient suppression of hematopoiesis in a murine experimental model during 10days. The aim of this study focuses on erythropoietin (EPO) receptor, GATA binding protein 1 (globin transcription factor 1) (GATA-1) and erythroid Krüppel-like factor (EKLF) expressions related to the apoptotic events triggered by paclitaxel in bone marrow and the subsequent in vivo erythropoietic recovery. Results showed a massive impairment of erythropoiesis early post paclitaxel administration (1-2days), which involved induction of high Bax/Bcl-xL ratio, caspase-3 activation, disruptions of the medullar niche and cell death by both apoptosis and necrosis. EPO receptor over-expression was noticed from day 3 onwards. It prompted the subsequent up-regulations of GATA-1 and EKLF transcription factors as well as of the anti apoptotic protein Bcl-xL, crucial proteins in driving erythropoiesis. This study suggests that EPO receptor recovery is necessary for the subsequent bone marrow ability to accomplish the erythroid program through the modulation of apoptotic and survival events after a single paclitaxel insult. These findings contribute to new insights into the molecular mechanisms involved during in vivo erythropoiesis post paclitaxel administration. Therefore, the detailed knowledge of the injury elicited by this drug on red blood cell production may have clinical relevance to explore new therapeutic approaches.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apoptosis
dc.subject
Eklf
dc.subject
Epo Receptor
dc.subject
Erythropoiesis
dc.subject
Gata-1
dc.subject
Paclitaxel
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Murine erythropoietic impairment induced by paclitaxel: Interactions of GATA-1 and erythroid Krüppel-like transcription factors, apoptotic related proteins and erythropoietin receptor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T21:53:53Z
dc.identifier.eissn
1879-0712
dc.journal.volume
636
dc.journal.number
1-3
dc.journal.pagination
42-51
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Aguirre, María Victoria. Universidad Nacional del Nordeste. Facultad de Medicina. Cátedra de Bioquímica; Argentina
dc.description.fil
Fil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Facultad de Medicina. Cátedra de Bioquímica; Argentina
dc.description.fil
Fil: Juaristi, Julian Antonio. Universidad Nacional del Nordeste. Facultad de Medicina. Cátedra de Bioquímica; Argentina
dc.description.fil
Fil: Brandan, Nora Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina. Cátedra de Bioquímica; Argentina
dc.journal.title
European Journal of Pharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejphar.2010.02.056
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299910002220
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