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dc.contributor.author
Low, Malcolm J.
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dc.contributor.author
Otero Corchon, Veronica
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dc.contributor.author
Parlow, Albert. F.
dc.contributor.author
Ramirez, Jose L.
dc.contributor.author
Kumar, Ujenda
dc.contributor.author
Patel, Yogesh C.
dc.contributor.author
Rubinstein, Marcelo
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dc.date.available
2019-07-10T19:55:11Z
dc.date.issued
2001-06
dc.identifier.citation
Low, Malcolm J.; Otero Corchon, Veronica; Parlow, Albert. F.; Ramirez, Jose L.; Kumar, Ujenda; et al.; Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth; American Society for Clinical Investigation; Journal of Clinical Investigation; 107; 12; 6-2001; 1571-1580
dc.identifier.issn
0021-9738
dc.identifier.uri
http://hdl.handle.net/11336/79325
dc.description.abstract
Pulsatile growth hormone (GH) secretion differs between males and females and regulates the sex-specific expression of cytochrome P450s in liver. Sex steroids influence the secretory dynamics of GH, but the neuroendocrine mechanisms have not been conclusively established. Because periventricular hypothalamic somatostatin (SST) expression is greater in males than in females, we generated knockout (Smst-/-) mice to investigate whether SST peptides are necessary for sexually differentiated GH secretion and action. Despite marked increases in nadir and median plasma GH levels in both sexes of Smst-/- compared with Smst+/+ mice, the mutant mice had growth curves identical to their sibling controls and retained a normal sexual dimorphism in weight and length. In contrast, the liver of male Smst-/- mice was feminized, resulting in an identical profile of GH-regulated hepatic mRNAs between male and female mutants. Male Smst-/- mice show higher expression of two SST receptors in the hypothalamus and pituitary than do females. These data indicate that SST is required to masculinize the ultradian GH rhythm by suppressing interpulse GH levels. In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Clinical Investigation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Somatostatina
dc.subject
Hormonas Hepáticas
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-05T17:31:59Z
dc.journal.volume
107
dc.journal.number
12
dc.journal.pagination
1571-1580
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Michigan
dc.description.fil
Fil: Low, Malcolm J.. Oregon Health And Science University; Estados Unidos
dc.description.fil
Fil: Otero Corchon, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Oregon Health And Science University; Estados Unidos
dc.description.fil
Fil: Parlow, Albert. F.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Ramirez, Jose L.. McGill University; Canadá
dc.description.fil
Fil: Kumar, Ujenda. McGill University; Canadá
dc.description.fil
Fil: Patel, Yogesh C.. McGill University; Canadá
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.journal.title
Journal of Clinical Investigation
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jci.org/articles/view/11941
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1172/JCI11941
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