Mostrar el registro sencillo del ítem
dc.contributor.author
Quinlan, Mark R.
dc.contributor.author
Cronin, Peter
dc.contributor.author
Daly, Padraig J.
dc.contributor.author
Watson, Ronald W. G.
dc.contributor.author
Manucha, Walter Ariel Fernando
dc.contributor.author
Docherty, Neil G.
dc.contributor.author
Fitzpatrick, John M.
dc.date.available
2019-07-10T14:28:37Z
dc.date.issued
2010-08
dc.identifier.citation
Quinlan, Mark R.; Cronin, Peter; Daly, Padraig J.; Watson, Ronald W. G.; Manucha, Walter Ariel Fernando; et al.; A gender comparison of postobstructive injury in the rat kidney; Karger; Kidney And Blood Pressure Research; 33; 4; 8-2010; 266-273
dc.identifier.issn
1420-4096
dc.identifier.uri
http://hdl.handle.net/11336/79284
dc.description.abstract
Background/Aims: Unilateral ureteral obstruction (UUO) results in renal injury. Studies report increased injury indices in male rats following UUO. Our study examined whether this gender-based renal response to UUO was reflected in sustained differences following relief of obstruction. Methods: Adult male/female rats (200-400 g) were subjected to either sham surgery (S/RN) or UUO (UUO/RN). At 24 h, obstruc- tion was relieved and all animals underwent contralateral nephrectomy. Five days after initial surgery, animals were placed in metabolic cages and given water ad libitum for 24 h followed by a 24-hour period of complete water restriction. On day 7, animals were euthanized and samples harvested. Tubular injury, urinary volume/osmolality, creatinine clearance, plasma arginine vasopressin, renal medullary V2 receptor and aquaporin 2 (AQP2) expression were measured. Results: Male UUO/RN rats showed increased renal apoptotic injury and reduced creatinine clearance rates (glomerular filtration rate) vs. females. No gender-dependent differences were observed in urinary osmolality or concentrating ability. AQP2 expression increased post-obstruction. Conclusion: Increased injury in males following UUO remains manifest during early recovery after release of obstruction. Despite this, the grade of postobstructive diuresis is not significantly altered between sexes. This may reflect reduced glomerular filtration rate and elevated AQP2 in male rats.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Apoptosis
dc.subject
Aquaporin
dc.subject
Diuresis
dc.subject
Ureteral Obstruction
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A gender comparison of postobstructive injury in the rat kidney
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T21:52:33Z
dc.identifier.eissn
1423-0143
dc.journal.volume
33
dc.journal.number
4
dc.journal.pagination
266-273
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Quinlan, Mark R.. The Conway Institute Of Biomolecular And Biomedical Science; Irlanda. University College Dublin; Irlanda
dc.description.fil
Fil: Cronin, Peter. University College Dublin; Irlanda
dc.description.fil
Fil: Daly, Padraig J.. University College Dublin; Irlanda. The Conway Institute Of Biomolecular And Biomedical Science; Irlanda
dc.description.fil
Fil: Watson, Ronald W. G.. The Conway Institute Of Biomolecular And Biomedical Science; Irlanda. University College Dublin; Irlanda
dc.description.fil
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Docherty, Neil G.. Trinity College Dublin; Irlanda
dc.description.fil
Fil: Fitzpatrick, John M.. University College Dublin; Irlanda. The Conway Institute Of Biomolecular And Biomedical Science; Irlanda. Mater Misericordiae University Hospital; Irlanda
dc.journal.title
Kidney And Blood Pressure Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000317934
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/article/Abstract/317934
Archivos asociados