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dc.contributor.author
Elmer, Greg I.
dc.contributor.author
Pieper, Jeanne O.
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Low, Malcolm J.
dc.contributor.author
Grandy, David K.
dc.contributor.author
Wise, Roy A.
dc.date.available
2019-07-05T18:26:46Z
dc.date.issued
2002-05
dc.identifier.citation
Elmer, Greg I.; Pieper, Jeanne O.; Rubinstein, Marcelo; Low, Malcolm J.; Grandy, David K.; et al.; Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice; Society for Neuroscience; Journal of Neuroscience; 22; 10; 5-2002; RC224-RC224
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/79264
dc.description.abstract
The rewarding effects of opiates are thought to be mediated through dopaminergic mechanisms in the ventral tegmental area, dopamine-independent mechanisms in the nucleus accumbens, or both. The purpose of the present study was to explore the contribution of dopamine to opiate-reinforced behavior using D2 receptor knock-out mice. Wild-type, heterozygous, and D2 knock-out mice were first trained to lever press for water reinforcement and then implanted with intravenous catheters. The ability of intravenously delivered morphine to maintain lever pressing in these mice was studied under two schedules of reinforcement: a fixed ratio 4 (FR4) schedule (saline, 0.1, 0.3, or 1.0 mg/kg, per injection) and a progressive ratio (PR) schedule (1.0 mg/kg, per injection). In the wild-type and heterozygous mice, FR4 behavior maintained by morphine injections was significantly greater than behavior maintained by vehicle injections. Response rate was inversely related to injection dose and increased significantly in the wild-type and heterozygous mice when the animals were placed on the PR schedule. In contrast, the knock-out mice did not respond more for morphine than for saline and did not respond more when increased ratios were required by the PR schedule. Thus, morphine served as a positive reinforcer in the wild-type and heterozygous mice but failed to do so in the knock-out mice. Under this range of doses and response requirements, the rewarding effects of morphine appear to depend critically on an intact D2 receptor system
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Morfina
dc.subject
Dopamina
dc.subject.classification
Neurociencias
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-05T17:31:44Z
dc.journal.volume
22
dc.journal.number
10
dc.journal.pagination
RC224-RC224
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Elmer, Greg I.. University of Maryland; Estados Unidos
dc.description.fil
Fil: Pieper, Jeanne O.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Low, Malcolm J.. Oregon Health and Sciences University; Estados Unidos
dc.description.fil
Fil: Grandy, David K.. Oregon Health and Sciences University; Estados Unidos
dc.description.fil
Fil: Wise, Roy A.. National Institutes of Health; Estados Unidos
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1523/JNEUROSCI.22-10-j0004.2002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/22/10/RC224
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